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ORIGINAL ARTICLE
Year : 2019  |  Volume : 15  |  Issue : 8  |  Page : 76-81

Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?


1 Department of Pediatric Surgery, Bezmialem Vakif University, Istanbul, Turkey
2 Department of Urology, Tepecik Teaching and Research Hospital, Izmir, Turkey
3 Department of Pathology, Bezmialem Vakif University, Istanbul, Turkey
4 Department of Radiation Oncology, Bezmialem Vakif University, Istanbul, Turkey
5 Department of Pathology, Ege University, Izmir, Turkey
6 Department of Urology, Medeniyet University, Istanbul, Turkey
7 Department of Urology, Ege University, Izmir, Turkey

Correspondence Address:
Prof. Rahmi Gokhan Ekin
Department of Urology, Tepecik Teaching and Research Hospital, Gaziler Caddesi, 35000, Yenisehir, Izmir
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_322_17

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Objective: We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)-induced testicular damage. Methods: Thirty healthy adult male Wistar rats divided into five groups consisting of six animals each as follows: (1) Control (C), (2) RT, (3) OT, (4) OT + RT, and (5) RT + OT group. Histopathological findings, Johnsen scores, thiobarbituric acid-reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were evaluated. Results: RT caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase, and GPx levels were significantly lower in the RT group when compared to the control group. Pre and postRT OT significantly increased GSH, SOD, catalase, and GPx levels and decreased TBARS level. Furthermore, testicular weight and Johnsen score were increased with OT. Conclusions: The present study showed that OT is protective and therapeutic in radiation-induced testicular damage. OT may be beneficial to the patients who underwent RT.


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