| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 14
| Issue : 6 | Page : 1373-1378 |
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CD105 (endoglin) expression as a prognostic marker of angiogenesis in squamous cell cervical cancer treated with radical radiotherapy
Evrim Metcalfe1, Deniz Arik2, Tufan Oge3, Durmus Etiz1, Omer Tarik Yalcin3, Sare Kabukcuoglu2, Ozgul Pasaoglu2, S Sinan Ozalp3
1 Department of Radiation Oncology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey
2 Department of Pathology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey
3 Department of Obstetrics and Gynecology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey
Correspondence Address:
Evrim Metcalfe
Department of Radiation Oncology, Eskisehir Osmangazi University Medical Faculty, Eskisehir
Turkey
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-1482.203602
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Introduction: Increased levels of endoglin may represent a new reagent of active neovascularization and angiogenesis process in various cancer types. The prognostic value of tumor CD105 (endoglin) expression in cervical squamous cell cancer (CSCC) patients treated with radical radiotherapy (RT) ± chemotherapy was investigated.
Materials and Methods: CD105 (endoglin) expression was assessed by immunohistochemical methods in seventy patients, who were treated with radical RT ± chemotherapy for CSCC. The prognostic effects of CD105 on patient and treatment characteristics, local-regional control, and survival were assessed.
Results: The median follow-up was 24 (5–99) months for the whole cohort. The median CD105 microvessel density was 55.5 (range; 12–136). Age (≤61 vs. >:61 years; P = 0.015), lymph node metastasis status (absent vs. present; P = 0.028), International Federation of Gynecology and Obstetrics stage (Ib–IIa vs. IIb–IVa; P = 0.036), cycles of concurrent chemotherapy (1–3 vs. 4–6 cycles; P = 0.001), and hemoglobin levels (≤10 g/dL vs. >:10 g/dL; P = 0.006) appeared to associate significantly with overall survival on univariate analysis.
Discussion: No correlation was identified between the tumor CD105 (endoglin) expression and survival in CSCC patients treated with radical RT ± chemotherapy.
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