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ORIGINAL ARTICLE
Year : 2018  |  Volume : 14  |  Issue : 2  |  Page : 314-320

The effects of gilaburu (Viburnum opulus) juice on experimentally induced Ehrlich ascites tumor in mice


1 Genome and Stem Cell Center, University of Erciyes, Kayseri, Turkey
2 Department of Biology, School of Arts and Sciences, University of Akdeniz, Antalya, Turkey
3 Department of Anatomy, School of Medicine, University of Erciyes, Kayseri, Turkey
4 Department of Histology and Embryology, School of Medicine, University of Erciyes, Kayseri, Turkey
5 Department of Pharmacognosis, School of Pharmacy, University of Erciyes, Kayseri, Turkey

Correspondence Address:
Dr. Dilek Ceylan
Genome and Stem Cell Center, University of Erciyes, Kayseri 38039
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.181173

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Objective: The aim of study was to investigate anticancer effect of Viburnum opulus (VO) on Ehrlich ascites carcinoma (EAC) bearing mice that treated with different concentrations of VO. Materials and Methods: For tumor transplantation; mice were inoculated with 1 × 106 EAC cells intraperitoneally and than divided into five groups (n = 9). Two hours after inoculation; experimental groups were treated daily with VO extract at doses of 1000 mg/kg, 2000 mg/kg, 4000 mg/kg. Results: Extracts obtained from gilaburu juice can have hinder effect on tumor cell growth. Conclusion: As far as we known, this is the first study about in vivo antitumoral activity of VOon Ehrlich ascites tumor model, and consequently VO extract exhibited anticancer activity against EAC-bearing mice.


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