Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 14  |  Issue : 1  |  Page : 119-123

Lipopolysaccharide promoted the growth rate of MG-63 cells via the extracellular regulated kinase pathway


Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China

Correspondence Address:
Dr. Hao Peng
Department of Orthopedics, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan, Hubei 430060
PR China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_673_17

Rights and Permissions

Objective: The objective of this study is to investigate the effects of lipopolysaccharide (LPS) on the growth rate of MG-63 cells. Materials and Methods: MG-63 cells were exposed to various concentrations of LPS, and the growth rate was determined with the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. In addition, variations in the phosphorylation state of extracellular regulated kinase (ERK1/2), Jun N-terminal kinase, and p38 were determined by western blotting. Results: There was a correlation between the increased phosphorylation of ERK1/2 and the growth of LPS-treated MG-63 cells. The increased phosphorylation was mediated by the LPS receptor toll-like receptor-4. Conclusions: LPS promoted the growth of MG-63 cells through the ERK pathway.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1634    
    Printed23    
    Emailed0    
    PDF Downloaded46    
    Comments [Add]    

Recommend this journal