|LETTER TO THE EDITOR
|Year : 2017 | Volume
| Issue : 2 | Page : 386-387
Oral cryotherapy for preventing chemotherapy-induced oral mucositis: An effective but yet neglected strategy
Hassan Sharifi1, Abbas Heydari2, Roham Salek3, Amir Emami Zeydi1
1 Student Research Committee, Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Medical-Surgical Nursing, Evidence-Based Caring Research Center, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
3 Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
|Date of Web Publication||23-Jun-2017|
Department of Medical-Surgical Nursing, Evidence-Based Caring Research Center, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Sharifi H, Heydari A, Salek R, Zeydi AE. Oral cryotherapy for preventing chemotherapy-induced oral mucositis: An effective but yet neglected strategy. J Can Res Ther 2017;13:386-7
|How to cite this URL:|
Sharifi H, Heydari A, Salek R, Zeydi AE. Oral cryotherapy for preventing chemotherapy-induced oral mucositis: An effective but yet neglected strategy. J Can Res Ther [serial online] 2017 [cited 2021 Sep 24];13:386-7. Available from: https://www.cancerjournal.net/text.asp?2017/13/2/386/188301
Oral mucositis (OM), as a toxic oral side effect of chemotherapy, threatens most of the patients receiving treatment for cancer, particularly those with high-dose chemotherapy. Chemotherapy-induced OM usually occurs about 5–7 days after treatment and might resolve within 3 weeks of treatment or not. OM ulcers lead to pain, difficulties with eating, swallowing, and talking, malnutrition, local and systemic infections, treatment delays, interrupting the treatment regimens, and ultimately increasing clinical morbidity.,
Several methods have been proposed for preventing chemotherapy-induced oral complications; among them is oral cryotherapy. Oral cryotherapy is the cooling of the mouth using ice, cold water, ice cream, or ice popsicles. It is well established that oral cryotherapy can prevent OM by reducing the penetration of chemotherapy agents in the mouth's mucous membrane with constriction of its blood vessel. It is confirmed in a recent Cochrane review that oral cryotherapy reduces OM of any severity in adults receiving fluorouracil-based chemotherapy for solid cancers. Further, there is a large reduction of severe OM in adults receiving high-dose melphalan-based chemotherapy before hematopoietic stem cell transplantation. The several advantages of oral cryotherapy such as availability, cost-effectiveness, ease of administration, safety, lack of side effects, tolerate ability by patients, and naturalness  encourage the doctors and nurses to apply this simple intervention.
However, our main concern is that why this simple intervention is not part of routine clinical practice. There is a critical need for more studies to investigate the facilitators and barriers for application of this effective but neglected strategy in prevention of chemotherapy-induced OM in daily practice. In addition, studies looking at the effect of oral cryotherapy in patients receiving different chemotherapy drugs are needed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| > References|| |
Scully C, Sonis S, Diz PD. Oral mucositis. Oral Dis 2006;12:229-41.
Peterson DE, Ohrn K, Bowen J, Fliedner M, Lees J, Loprinzi C, et al.
Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy. Support Care Cancer 2013;21:327-32.
Riley P, Glenny AM, Worthington HV, Littlewood A, Clarkson JE, McCabe MG. Interventions for preventing oral mucositis in patients with cancer receiving treatment: Oral cryotherapy. Cochrane Database Syst Rev 2015;12:CD011552.
Wang L, Gu Z, Zhai R, Zhao S, Luo L, Li D, et al.
Efficacy of oral cryotherapy on oral mucositis prevention in patients with hematological malignancies undergoing hematopoietic stem cell transplantation: A meta-analysis of randomized controlled trials. PLoS One 2015;10:e0128763.
Heydari A, Sharifi H, Salek R. Effect of oral cryotherapy on combination chemotherapy-induced oral mucositis: A randomized clinical trial. Middle East J Cancer 2012;3:55-64.