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ABSTRACT
Year : 2016  |  Volume : 12  |  Issue : 6  |  Page : 80

Pediatrics


Date of Web Publication30-Nov-2016

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How to cite this article:
. Pediatrics. J Can Res Ther 2016;12, Suppl S2:80

How to cite this URL:
. Pediatrics. J Can Res Ther [serial online] 2016 [cited 2021 Mar 1];12:80. Available from: https://www.cancerjournal.net/text.asp?2016/12/6/80/194972

Abstract: 262

Treatment of paediatric malignancies without anesthesia: A feasible method

A. N. Aswin , G. Selvaluxmy

Department of Radiotherapy, Cancer Institute (WIA), Chennai, Tamil Nadu, India, E-mail: [email protected]

Introduction: The main aim of this study is to provide safe Radiation delivery in children with malignancies without anesthesia. Materials and Methods: 27 children were treated without anesthesia from January 2015 to August 2016. The malignancies treated were ALL (22%), RMS & Ewing's Sarcoma (19% each), Lymphomas (15%), Wilm's tumor (11%), Nasopharynx and Brain tumors (7% each). 15 children were between 3-7 years group and remaining 12 were between 8-12 years age group. Results: The latter age group children were co-operative and completed the treatment without anxiety. Though the former age group children had anxiety in the beginning, they completed the treatment without anesthesia with the help of distraction techniques. The planning, delivery and after care of radiotherapy for children is a complex multi-professional activity. It requires Clinical Oncologists, Radiotherapists, Mould room staff, Play specialists, Nurses, Physicists, Dosimetrists and Psychologists. Multiple visits to the mould and treatment room are required in order to get familiarity with the treatment place and to reduce anxiety. Immobilization and simulation were done in a child friendly environment with distraction aids. The children were treated daily in the same machine, so that they were familiar with the treating personnel. Daily set up verification of portals were done prior to delivery. Conclusions: Children of different ages have different needs. Careful explanation and listening to and responding sympathetically to concerns, is essential to achieve understanding and to reduce stress and anxiety. Although the process is time consuming, time must be made available in order to make the treatment safe and effective.

Abstract: 38

Analysis of clinical outcome in patients with atypical teratoid/rhabdoid tumour: A retrospective analysis

Asha Arjunan , Gouri Somanath, P. Kusuma Kumari, T. Priyakumari, Anitha Mathews, R. Binitha, T. Manjusha, Jagath Krishna,

Beela Sarah Mathew, K. Ratheesan

Department of Radiotherapy, Regional Cancer Centre, Thiruvananthapuram, Kerala, India, E-mail: [email protected]

Introduction: Atypical teratoid/rhabdoid tumor (ATRT) is a highly malignant central nervous system neoplasm in early childhood. It was added to the World Health Organization Classification of Tumours of the Central Nervous System in 2000. We retrospectively evaluated the treatment outcomes for ATRT at our institute. Materials and Methods: Clinical data on patients with histologically proven ATRT since Jan 2005 were reviewed. Overall survival (OS) and progression free survival (PFS) were calculated from date of surgery. Progression was determined as date of first radiologic evidence of disease recurrence/progression. Results: 10 patients were identified, 5 females & 5 males. Median age at diagnosis: 7 years (range: 1-15 years). 4 patients were ≤3 years of age. 2 patients had cerebrospinal dissemination at diagnosis. All children underwent surgery as primary treatment (Gross Tumour Resection-5, Subtotal Resection-5). 4 patients did not receive adjuvant treatment due to poor general condition. 1 child aged <3 years received chemotherapy alone and 3 children received chemotherapy and CSI (30 to 36.0 Gy to neuraxis with boost of 54.0-55 Gy). 1 child received focal radiotherapy alone (55.8 Gy). Median follow- up was 74 months (range, 46-101 months). Only 2 patients (20%) were alive at the time of analysis. Median survival was 6 months. Both the children who are alive underwent GTR followed by CSI and chemotherapy. OS at 2 year was 30%. Conclusions: Our results are comparable with existing literature reports which show that children with ATRT have a poor prognosis, however long-term survival is possible in some children.

Abstract: 85

To evaluate the frequency CNS relapse after prophylactic cranial irradiation in pediatric patients (age 1-9 years) of acute lymphoblastic leukaemia: A retrospective study

Ashutosh Das Sharma , Jyoti Poddar, Sonal Patel Shah, U. Suryanarayana, Ankita Parikh, Maitrik Mehta

Department of Radiotherapy, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India, E-mail: [email protected]

Aim:
To analyse the frequency of CNS relapse in pediatric patients of ALL after receiving Prophylactic Cranial Irradiation. Materials and Methods: A retrospective single arm study of 179 patients of High risk ALL (of age >1 year and <10 year) was done treated between January 2012 to December 2013. All the patients were administered MCP 841 chemotherapy regimen, and received prophylactic cranial irradiation (18 Gray/10 #) as part of the treatment protocol. The patients were followed up after the completion of radiation for a median follow up time of 30 months for development of CNS relapse. Results: Out of 179 patients, 15 had CNS relapse. 9 were CSF positive relapse, 6 were Clinical relapse. Out of the total 15 CNS relapse, 4 were isolated CNS relapse. The minimum time interval after PCI when CNS relapse was seen was 3 mnths and maximum was 45 mnths with a median disease free survival of 30 mnths. The CNS disease free survival was calculated by multivariate analysis and Kaplan Meier survival plots. Conclusions: PCI can still be contemplated in patients of ALL for preventing CNS relapse where newer chemotherapy regimens are beyond the reach of the patient and where chemotherapy tolerance and treatment compliance are important issues. Though it is challenged because of the long term side effects of radiation, PCI still holds good in low and middle income countries.




 

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