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ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 5  |  Page : 50-53

The association between runt-related transcription factor 3 gene promoter methylation and gastric cancer: A meta-analysis


1 Department of Clinical Laboratory, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China
2 Department of Clinical Laboratory, The Second People's Hospital, Tianjin 300192, China

Correspondence Address:
Xu Liu
Department of Clinical Laboratory, First Teaching Hospital of Tianjin University of TCM, Tianjin 300193
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.191630

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Objective: To systematically evaluate the relationship of the methylation of the human-runt-related transcription factor 3 (RUNX3) promoter region and gastric cancer risk through meta-analysis. Materials and Methods: The studies published in PubMed, EMBASE, Ovid, and CNKI were retrieved. The association between RUNX3 gene promoter methylation and gastric cancer was analyzed using Stata 11.0 (http://www.stata.com; Stata Corporation, College Station, TX, USA) and Review Man 5.0 software (http://ims.cochrane.org/revman/download). Results: Seventeen studies are included in the analysis. Meta-analysis reveals that the odds ratio of the methylation of the RUNX3 promoter region in gastric was 7.32 (95% confidence interval: 5.12–10.47), which was significant higher than the normal gastric tissues (P < 0.05). Conclusions: The RUNX3 gene promoter methylation rate was much higher in tumor tissue than that in normal gastric tissue in patient with gastric cancer, which indicates a close association between gastric cancer and RUNX3 gene promoter methylation.


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