| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 12
| Issue : 1 | Page : 58-61 |
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Bioinformatic analysis of c-Myc target from laryngeal cancer cell gene of laryngeal cancer
Wei-Dong Zhang1, He-Xin Chen2, Yun-Xia Wang3, Zhi-Ping Chen4, Zhong-Jie Shan1, Guang Xu1
1 Department of Otorhinolaryngology, People's Hospital of Zhengzhou, Henan, Henan Province, China
2 Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat Sen University, Guangdong, China
3 Department of Stomatology, People's Hospital of Zhengzhou, Henan, Henan Province, China
4 Department of Radiology, Children's Hospital of Zhengzhou, Henan Province, China
Correspondence Address:
Wei-Dong Zhang
No. 33, Huanghe Road, Zhengzhou, Henan Province
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-1482.146083
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Aim of Study: The aim was to explore the structure and functions of new target spot c-Myc target from laryngeal cancer cell. (MTLC) of c-Myc gene.
Methods: This study adopted bioinformatic methods to analyze the physicochemical property, secondary structure, hydrophobic region, a transmembrane region, and prediction of functions.
Results: The results showed that the whole length of the open reading frames was 708 bp, coding was 235 amino acids. This protein was a basic protein possessed two transmembrane structures and weight was about 26592.5 Da. The main elements of secondary structure were alpha-helix and random coil. MTLC was a membrane constitutive protein that possessed signal transduction and regulation may locate on karyotheca as results of subcellular localization and function prediction.
Conclusion: This study has provided the theoretical basis for the further discussion of the effect and mechanism of action of MTLC in the occurrence of laryngeal cancer. |
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