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Year : 2016  |  Volume : 12  |  Issue : 1  |  Page : 28-35

Seesaw of matrix metalloproteinases (MMPs)


1 Department of Oral Pathology and Microbiology, Bhojia Dental College, Baddi, Solan, India
2 Department of Prosthodontics and Implantology, Himachal Dental College, Sundernagar, Mandi, H.P, India
3 Department of Oral Pathology and Microbiology, Subharti Dental College, Meerut, U.P, India
4 Department of Oral Pathology and Microbiology, Manav Rachna Dental College, Faridabad, Haryana, India
5 Paradise Diagnostics, Delhi, India

Correspondence Address:
Charu Kapoor
Department of Oral Pathology and Microbiology, Bhojia Dental College, Budd, Baddi, Solan, Himachal Pradesh - 176 001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.157337

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The family of human matrix metalloproteinases (MMPs) comprises several tightly regulated classes of proteases. These enzymes and their specific inhibitors play important roles in tumor progression and the metastatic process by facilitating extracellular matrix (ECM) degradation. As scientific understanding of the MMPs has advanced, therapeutic strategies focusing on blocking these enzymes by MMP inhibitors (MMPIs) have rapidly developed. This paper reviews MMPs in detail. Their perspectives in therapeutic intervention in cancer are also mentioned.


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