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Year : 2016  |  Volume : 12  |  Issue : 1  |  Page : 277-282

Increased osteopontin protein expression may be correlated with poor prognosis in non-small-cell lung cancer: A meta analysis

1 Department of Respiratory Medicine, China-Japan Union Hospital of JiLin University, Changchun 130031, Jilin Province, P.R.China
2 Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130031, Jilin Province, P.R.China
3 Department of Respiratory Medicine, Jinhua Central Hospital, Jinhua, P.R.China

Correspondence Address:
Jing Wang
Department of Respiratory Medicine, China-Japan Union Hospital of JiLin, Xiantai Street 126, Changchun 130031, Jilin Province
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.150362

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Aim: The present meta-nalysis investigates the prognostic value of osteopontin. (OPN) expression in patients with non-small-cell lung cancer. (NSCLC). Materials and Methods: The Web of Science (1945 ~ 2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966 ~ 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013) were searched, without language restrictions, to retrieve studies related to OPN and NSCLC. We compiled carefully selected data and a meta-analysis was conducted using STATA software (Version 12.0, Stata Corporation, and College Station, Texas USA). Hazard ratios (HR) with corresponding 95% confidence interval (95%CI) were calculated. Results: Ten clinical cohort studies were selected for statistical analysis, representing a total of 1,133 NSCLC patients. The main findings of our meta-analysis are that patients who were OPN-positive had significantly shorter overall survival than OPN-negative patients. (HR = 1.47, 95%CI = 1.15. ~ 1.79,P< 0.001). Ethnicity.stratified analysis revealed a significant correlation between expression levels of OPN and poor prognosis of NSCLC patients among both Caucasians and Asians. (Asians: HR = 1.53, 95%CI = 0.95. ~ 2.11, P < 0.001; Caucasians: HR = 1.56, 95%CI = 1.08. ~ 2.03, P < 0.001; respectively). Conclusions: The present meta-analysis is consistent with the hypothesis that increased expression of OPN protein may be significantly associated with poor prognosis in patients with NSCLC.

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