Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells
Zhenhe Huang1, Xueqin Huang2, Donghui Jiang3, Yuefei Zhang4, Bo Huang3, Guoqing Luo4
1 Department of Otolaryngology, Ganzhou People's Hospital, Ganzhou, Jiangxi, 341000, China
2 Department of Otolaryngology, The Second Clinical College of Guangdong Medical College, Dongguan, Guangdong, China
3 The First Affiliated Hospital of Guangdong Medical College, Guangdong Medical College, Zhanjiang, Guangdong, 524023, China
4 The First Affiliated Hospital of Guangdong Medical College; Department of Otolaryngology, Guangdong Medical College, Zhanjiang, Guangdong, 524023, China
Department of Otolaryngology, First Affiliated Hospital of Guangdong Medical College, Zhanjiang - 524023, Guangdong
Source of Support: None, Conflict of Interest: None
Context: Dihydroartemisinin (DHA) exhibits anticancer activity in a number of human cancer cells. However, it is still unknown whether DHA has anticancer effect on nasopharyngeal cancer (NPC) cells.
Aims: To investigate the anticancer activity of DHA on CNE-2 cells.
Materials and Methods: Cell cycleand invasion assay were used to detect the effect of DHA on CNE-2 cells. Protein molecular differences were examined by Western blot.
Results: DHA strongly inhibited cell proliferation by induced cell cycle G1 arrest and apoptosis in CNE-2 cells. In addition, cell motility, invasion, and colony formation were suppressed by DHA.
Conclusions: DHA shows significant anticancer effects on human NPC cells, and may be a preventive and therapeutic agent against NPC.