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ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 1  |  Page : 244-247

Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells


1 Department of Otolaryngology, Ganzhou People's Hospital, Ganzhou, Jiangxi, 341000, China
2 Department of Otolaryngology, The Second Clinical College of Guangdong Medical College, Dongguan, Guangdong, China
3 The First Affiliated Hospital of Guangdong Medical College, Guangdong Medical College, Zhanjiang, Guangdong, 524023, China
4 The First Affiliated Hospital of Guangdong Medical College; Department of Otolaryngology, Guangdong Medical College, Zhanjiang, Guangdong, 524023, China

Correspondence Address:
Guoqing Luo
Department of Otolaryngology, First Affiliated Hospital of Guangdong Medical College, Zhanjiang - 524023, Guangdong
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.151855

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Context: Dihydroartemisinin (DHA) exhibits anticancer activity in a number of human cancer cells. However, it is still unknown whether DHA has anticancer effect on nasopharyngeal cancer (NPC) cells. Aims: To investigate the anticancer activity of DHA on CNE-2 cells. Materials and Methods: Cell cycleand invasion assay were used to detect the effect of DHA on CNE-2 cells. Protein molecular differences were examined by Western blot. Results: DHA strongly inhibited cell proliferation by induced cell cycle G1 arrest and apoptosis in CNE-2 cells. In addition, cell motility, invasion, and colony formation were suppressed by DHA. Conclusions: DHA shows significant anticancer effects on human NPC cells, and may be a preventive and therapeutic agent against NPC.


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