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Year : 2016  |  Volume : 12  |  Issue : 1  |  Page : 126-130

Is there an association between oral submucous fibrosis and ABO blood grouping?

1 Department of Public Health Dentistry, People's College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India
2 Department of Periodontics, RKDF Dental College, Bhopal, Madhya Pradesh, India
3 Department of Public Health Dentistry, People's Dental Academy, Bhopal, Madhya Pradesh, India
4 Department of Oral Medicine and Radiology, Governament Dental College, Shimla, Himachal Pradesh, India
5 Department of Physiotherapy, Southern Institute of Medical Sciences College of Physiotherapy, Guntur, Andhra Pradesh, India
6 Department of English, People's College of Research and Technology, Bhopal, Madhya Pradesh, India

Correspondence Address:
Venu K Gopal Reddy
Department of Public Health Dentistry, People's College of Dental Sciences and Research Centre, Bhopal - 462 037, Madhya Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.151857

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Background: Oral submucous fibrosis (OSMF) is one of the most common premalignant conditions in Indian subcontinent due to the traditional use of Areca nut and its various preparations. The genetic predisposition has also been reported in its etiopathogenesis. The rate of malignant transformation is between 7% to 14%. Aim: To evaluate whether ABO blood group is related to OSMF risk. Subjects and Methods: It was a cross-sectional hospital-based study. A convenient sample of 164 study subjects constituted the cases and 180 subjects constituted the comparison group. Statistical Analysis Used: The results were analyzed using chi-square test and odds ratio. Results: The chi-square analysis could not establish any significant relationship between OSMF and ABO blood group. But, when the strength of the association was measured using odds ratio, subjects with blood group A had 1.181 times higher risk of developing OSMF in comparison to other groups. Conclusion: The subjects with blood group A were at higher risk of developing OSMF in comparison to others. By performing blood group determination using a routine method at outreach programs, the susceptible individuals can be identified and counselled to quit the habit, thereby avoiding potential complications.

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