Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2016  |  Volume : 12  |  Issue : 1  |  Page : 117-120

A retrospective analysis of serum tumor markers found in non-small cell lung cancer

1 Department of Radiotherapy, Jiangsu Cancer Hospital, Nanjing, China
2 Department of Cardio-Thoracic Surgery, Second Affiliated Hospital of Nantong University, Nantong, China
3 Department of Plastic Surgery, Eighth People's Hospital of Shanghai, Shanghai, China

Correspondence Address:
Pijun Yu
Department of Plastic Surgery, The Eighth People's Hospital of Shanghai, 8 Caobao Road, Shanghai, 200235
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.151424

Rights and Permissions

Aim: This paper discusses the retrospective analysis conducted to determine the significance of diagnostic biomarkers, carcinoembryonic antigens (CEA), cytokeratin fragment antigens 21-1 (CYFRA 21-1), neuron-specific enolases (NSE), and tumor-specific growth factors (TSGF) upon patients who suffered with non-small cell lung cancer (NSCLC). Materials and Methods: From June 2010 to December 2011, we analyzed the positive rates of biomarkers in 276 NSCLC patients. We assessed the relationship between biomarkers and clinical characteristics of sex, smoking history, and disease stage. Results: The median and positive rates of each serum biomarker were marked as 1.91–22.77 ng/ml and 35.86% (CEA), 2.0–6.77 ng/ml and 50% (CYFRA 21-1), 13.91–23.78 ng/ml and 62.31% (NSE), and 56–67 μ/ml and 10.14% (TSGF). The level of CEA in peripheral (2.43–23.76 ng/ml) was significantly higher than the level at central position (1.97–3.63 ng/ml) (P < 0.05). Conclusion: Although the positive CEA, CYFRA 21-1, NSE, and TSGF rates were observed at low values during the NSLCLC serum diagnosis, they still played an important role in diagnosing lung cancer. Significant levels of CEA, CYFRA 21-1, NSE, and TSGF were detected in the serum. The amounts found were useful for diagnosing NSCLC patients who depended on the currently limited biomarker development.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded170    
    Comments [Add]    

Recommend this journal