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ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 6  |  Page : 222-225

Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials


Department of Otolaryngology, Head and Neck Surgery, Tianjin Union Medicine Centre, Tianjin 300000, PR, China

Correspondence Address:
Shengli Wei
Department of Otolaryngology, Head and Neck Surgery, Tianjin Union Medicine Centre, Tianjin 300000
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.168190

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Objective: We performed this meta-analysis to assess the metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma. Materials and Methods: Two reviewers independently reviewed the databases of PubMed and CNKI. The prospective, randomized, controlled trials of metronidazole amino acidum natrium combined with radiation versus radiotherapy alone in the treatment of nasopharyngeal carcinoma were included in this meta-analysis. The objective response rate (RR) of 1-, 3-, and 5-year survival rates were pooled by statistical software. The publication bias was evaluated by Begg's funnel plot. Results: Sixteen prospective, randomized, controlled trials were finally included in this meta-analysis. The quality assessment showed that the method's quality was relatively poor. The pooled results showed that the metronidazole amino acidum natrium combined with radiation can significantly improve the objective RR for the primary lesion (RR = 1.37, 95% confidence interval [CI]: 1.23–1.53, P < 0.05) and neck metastasis lesion (RR = 1.36, 95% CI: 1.25–1.49, P < 0.05). For survival analysis, the combined treatment can significantly improve the 1-year survival (RR = 1.57, 95% CI: 1.28–1.93, P < 0.05), 3-year survival (RR = 1.23, 95% CI: 1.06–1.41, P < 0.05), and 5-year survival rates (RR = 1.27, 95% CI: 1.05–1.53, P < 0.05). Conclusion: Metronidazole amino acidum natrium combined with radiation can improve the objective RR and long-term survival compared to radiation therapy alone in the treatment of nasopharyngeal carcinoma.


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