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Year : 2015  |  Volume : 11  |  Issue : 3  |  Page : 665

Villous adenoma of the urinary bladder

Department of Urology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India

Date of Web Publication9-Oct-2015

Correspondence Address:
Dilip Kumar Pal
Department of Urology, Institute of Post Graduate Medical Education and Research, 244, AJC Bose Road, Kolkata - 700 020, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.144360

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 > Abstract 

Villous adenoma is a known entity in the gastrointestinal tract, but very rare in the urinary tract. It is a benign tumor with excellent prognosis, but its progression to adenocarcinoma is not established. Here, we report an additional case of villous adenoma of the urinary bladder.

Keywords: Tubulovillous adenoma, urinary bladder, villous adenoma

How to cite this article:
Pal DK. Villous adenoma of the urinary bladder. J Can Res Ther 2015;11:665

How to cite this URL:
Pal DK. Villous adenoma of the urinary bladder. J Can Res Ther [serial online] 2015 [cited 2021 Jun 24];11:665. Available from: https://www.cancerjournal.net/text.asp?2015/11/3/665/144360

 > Introduction Top

Villous adenoma of the urinary tract is very rare. [1],[2],[3],[4],[5] Most of the cases are reported as a case report, and until now only two case series are published. [2],[3] Histopathologically it is identical to the villous adenoma of the intestinal tract. We report a case of villous adenoma of the urinary bladder with a successful outcome.

 > Case report Top

A 45-year-old woman presented with two episodes of gross hematuria 2 months back. Since then, she suffered from irritable bladder symptoms. On physical examination, no abnormality was detected. Urinalysis was normal and urine culture revealed no growth. She was normoglycemic with normal renal biochemical parameters. On ultrasonography (USG), a large growth was found in the right posterolateral wall with a broad base. Contrast-enhanced computed tomography (CT) revealed a 5 cm × 3 cm enhancing polypoid mass in the right posterolateral wall of the urinary bladder without any extravesical extension [Figure 1]. Cystoscopy confirmed the same findings, transurethral resection of the tumor with coagulation of the base done. Histopathological examination suggested it to be a villous adenoma with focal dysplastic changes [Figure 2] and typical goblet cells without any muscular or lymphovascular invasion [Figure 3]. Immunohistochemistry showed positive staining for cytokeratine (CK)-7 and 20 and carcinoembryonic antigen (CEA).
Figure 1: Contrast-enhanced computed tomography showing a bladder mass in the right posterolateral wall

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Figure 2: Microphotograph showing bladder muscle with stromal component with villous adenoma (H and E, ×40)

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Figure 3: Microphotograph showing bladder smooth muscle on one side with villous adenoma. The adenoma shows typical goblet cells without any invasion (H and E, ×400)

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 > Discussion Top

Villous adenoma of the urinary tract is rarely reported in the literature, and until now only 10 cases are reported. [3] The age of the reported cases ranged from 33 to 79 years with a median range of 57 years. [3] The usual clinical presentation is with hematuria and chronic irritative urinary symptoms. [2],[3],[4] There is no specific findings in USG, CT, magnetic resonance imaging or in cystoscopy to differentiate it preoperatively from usual urothelial carcinoma. [4] Histologically urinary tract villous adenomas are identical to the colonic villous adenomas. Both of them have rounded projection of pseudo-stratified columnar epithelium with goblet type mucin secreting cells. [3] Both these lesions are positive with immunohistochemical staining for CK-20 and CEA, but negative for epithelial membrane antigen. Only 50% of urinary tract villous adenomas show positivity for CK-7, in contrast to the most of the cases of intestinal origin. [2] The differential diagnosis of villous adenoma includes cystitis glandularis and well-differentiated adenocarcinoma. [2],[3] Both of them do not show a well-formed villous structure, which is typical of villous adenoma, but the latter shows pseudostratified epithelium with enlarged hyperchromatic nucli, which is absent in cystitis glandularis. [5] Though coexisting adenocarcinoma with villous adenoma has been reported in two cases, [4],[6] there is no evidence to support that villous adenoma may progress to adenocarcinoma. [4] Until now, there is only one case report of urethral villous adenoma, which has progressed to villous adenocarcinoma, [7] The prognosis of this tumor is excellent. [4] but follow-up cystoscopy is necessary in order to find any recurrence as well as a coexisting carcinoma. [4]

 > References Top

Chaudhuri A, Sandhu DP, Xuereb J. Villous adenoma of the urinary bladder. BJU Int 1999;84:177-8.  Back to cited text no. 1
Seibel JL, Prasad S, Weiss RE, Bancila E, Epstein JI. Villous adenoma of the urinary tract: A lesion frequently associated with malignancy. Hum Pathol 2002;33:236-41.  Back to cited text no. 2
Sung W, Park BD, Lee S, Chang SG. Villous adenoma of the urinary bladder. Int J Urol 2008;15:551-3.  Back to cited text no. 3
Kato Y, Konari S, Obara W, Sugai T, Fujioka T. Concurrence of villous adenoma and non-muscle invasive bladder cancer arising in the bladder: A case report and review of the literature. BMC Urol 2013;13:36.  Back to cited text no. 4
Daroca PJ Jr, Mackenzie F, Reed RJ, Keane JM. Primary adenovillous carcinoma of the bladder. J Urol 1976;115:41-5.  Back to cited text no. 5
Thomas DG, Ward AM, Williams JL. A study of 52 cases of adenocarcinoma of the bladder. Br J Urol 1971;43:4-15.  Back to cited text no. 6
Powell I, Cartwright H, Jano F. Villous adenoma and adenocarcinoma of female urethra. Urology 1981;18:612-4.  Back to cited text no. 7


  [Figure 1], [Figure 2], [Figure 3]


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