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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 8  |  Page : 292-295

The relationship between P16 gene promoter methylation and gastric cancer: A meta-analysis based on Chinese patients


1 Department of Medical Oncology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022; First Department of Surgical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China
2 Department of General Surgery, The Central Hospital of Lishui City, Lishui, Zhejiang 323000, China
3 Department of Medical Oncology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China

Correspondence Address:
Guoping Sun
Department of Medical Oncology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.151535

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Objective: To evaluate the P16 gene promoter methylation rate in gastric cancer tissue and healthy controls. And further assess the clinical value of P16 gene promoter methylation as a biomarker for gastric cancer diagnosis. Materials and Methods: Four databases, Medline, VIP, CNKI, WANFANG were searched to find the diagnostic trials about P16 gene promoter methylation in gastric cancer and healthy control. The pooled sensitivity, specificity, positive likelihood ratio (+LR), negative likelihood ratio (-LR) and the receiver operating characteristic curve (ROC) were calculated by Meta-DiSc1.4 (http://www.hrc.es/investigacion/metadisc.html) software. Results: Nine studies involving 487 gastric cancer patients and 271 healthy controls were included in this meta-analysis. The median methylation rate for gastric cancer group was 43.3% with its range of 28.3-64.4%. And the median methylation rate for healthy control group was 0.0% with its range of 0.0-13.3%. The methylation rate in gastric cancer was statistical higher than in the healthy control (P < 0.05). The pooled sensitivity, specificity, +LR, -LR and the area under the ROC curve were 0.44 (95% confidence interval [CI]: 0.40-0.49), 0.97 (95% CI: 0.95-0.99), 13.11 (95% CI: 4.02-42.63), 0.58 (95% CI: 0.49-0.70), 23.62 (95% CI: 6.90-80.90) and 0.44, respectively. Conclusion: Our meta-analysis indicates that P16 gene promoter methylation array is a useful method for diagnosis of gastric cancer with relatively low sensitivity and very high specificity.


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