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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 8  |  Page : 256-258

Metastatic brain tumors from small-cell esophageal cancer: Clinical characteristics and outcome


1 Department of Radiation Oncology, Zhejiang Key Laboratory of Radiation Oncology, Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (Lung and Esophagus), Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P. R. China; Division of Radiation Oncology, Shizuoka Cancer Center, Shizuoka, Japan
2 Division of Radiation Oncology, Shizuoka Cancer Center, Shizuoka, Japan
3 Department of Radiation Oncology, Zhejiang Key Laboratory of Radiation Oncology, Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (Lung and Esophagus), Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P. R. China
4 Division of Neurosurgery, Shizuoka Cancer Center, Shizuoka, Japan
5 Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan

Correspondence Address:
Hideyuki Harada
1007, Shimonagakubo, Nagaizumi-Cho., Shizuoka, Japan

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Source of Support: This work was supported by grants from the Zhejiang Province Science and Technology Project of Traditional Chinese Medicine (2011ZB017) and the Talent Project of Medical and Health Sciences Fund of Zhejiang Province (2012RCB005), Conflict of Interest: None


DOI: 10.4103/0973-1482.151469

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Aims: Few studies have examined the clinical characteristics of patients with brain metastases from small-cell esophageal cancer. In this study, we review the clinical characteristics and outcomes in patients with brain metastases from small-cell esophageal cancer. Patients and Methods: From August 2002 to August 2012, consecutive patients diagnosed with brain metastases from small-cell esophageal cancer and treated with radiotherapy were enrolled. Clinical features, diagnostic findings, and survival were analyzed. Results: Six patients treated with brain radiotherapy were identified. The median age was 64 (range 61-74) years. All patients had neurological impairments. Three patients had supra- and infra-tentorial metastases, and three patients had cerebrum metastases. Brain metastases were detected when esophageal cancer was initially diagnosed in two patients. In three patients, magnetic resonance imaging findings after radiotherapy confirmed a significant response to treatment. The median overall survival was 6.0 months. During the same period, 43 patients with squamous cell carcinoma and seven patients with adenocarcinoma who had brain metastases were identified. Survival periods for squamous cell carcinoma and adenocarcinoma patients who had brain metastases were 5.5 months and 4.2 months, respectively. There was no significant difference in overall survival according to the histological type. Conclusions: Brain metastases from small-cell esophageal cancer tend to spread to the cerebellum and impair patients' quality-of-life. Brain radiotherapy had a positive effect in this case series; however, overall survival remains short.


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