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Year : 2014  |  Volume : 10  |  Issue : 5  |  Page : 65-69

The inhibitory effect of Shaoyao Ruangan formula on mice with transplanted H22 hepatocarcinoma and its mechanism research

1 Department of Pharmacy, Zhengjiang Cancer Hospital, Hangzhou, Zhejiang, China
2 Department of Pharmacy, Zhejiang Cancer Research Institute, Zhengjiang Cancer Hospital, Hangzhou, Zhejiang, China

Correspondence Address:
Hong-yan Zhang
Zhengjiang Cancer Hospital, Hangzhou 310022
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Source of Support: This study was supported by Traditional Chinese medicine scientific research fund project of Zhejiang province. Equipment used in this study was provided by Zhejiang Cancer Research Institute, Conflict of Interest: None

DOI: 10.4103/0973-1482.139765

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Background: The incidence of hepatocellular carcinoma (HCC) is very high in the world. However, a safe and effective strategy is still under research. Aims: Our aim was to demonstrate the inhibitory effect of Shaoyao Ruangan Formmula (SRF) on the tumor of H22-bearing mice and explore its antitumor mechanisms. Settings and Design: Corresponding physiological indexes of H22-bearing mice treated with SRF were compared with that of saline treated mice, which could reflect the tumor-suppressing effect of SRF. Materials and Methods: After treatment, tumor weight, survival time, related gene expression levels etc., were recorded or detected. Statistical Analysis: Data analyzed using a computer SPSS program. Results and Conclusions: Comparing with blank control group, the tumor inhibitor rate (IR) of low, middle and high dose group of SRF was 17.72%, 33.99% and 23.73%, respectively. IR of CTX was 43.95%. The results also showed that each group of SRF could prolong the life span of H22-bearing mice to some extent. In addition, reverse transcription polymerase chain reaction (RT-PCR) results revealed that SRF was able to influence related genes expression in the tumor tissues of H22-bearing mice. The expression of TGF-β receptor type II (TBRII) gene was significantly upregulated in each SRF group comparing with normal saline group. On the contrary, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) was significantly downregulated in each SRF group comparing with normal saline group. In summary, SRF showed tumor-suppressing effect on mice with transplanted H22 hepatocarcinoma. The mechanism of antitumor effect may induced by upregulating TBRII expression and down-regulating NF-κB expression.

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