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Year : 2014  |  Volume : 10  |  Issue : 5  |  Page : 1-2

Anti-tumor effects of traditional Chinese medicine give a promising perspective

Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (Lung and Esophagus), Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China

Date of Web Publication30-Aug-2014

Correspondence Address:
Weimin Mao
Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (Lung and Esophagus), Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.139741

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How to cite this article:
Xia Q, Mao W. Anti-tumor effects of traditional Chinese medicine give a promising perspective. J Can Res Ther 2014;10, Suppl S1:1-2

How to cite this URL:
Xia Q, Mao W. Anti-tumor effects of traditional Chinese medicine give a promising perspective. J Can Res Ther [serial online] 2014 [cited 2021 Mar 2];10:1-2. Available from: https://www.cancerjournal.net/text.asp?2014/10/5/1/139741

Natural products provide a vast resource for the development of anti-tumor drugs, which have been investigated for decades. [1] Due to the high morbidity and mortality of malignant tumors, current therapeutics tend to combination strategies, in which molecular targeted chemotherapy are commonly used. Traditional Chinese medicine (TCM) functions as chemotherapy or adjuvant chemotherapy attracted much attention for easy to obtain and exhibited significant anti-tumor effects accompanied with less toxic and side effects. [2],[3] Many extracts from TCM are investigated in labs and also in clinical trials. [4] This issue will focus on natural products as therapy in the treatment of malignant tumors, with TCM as an emphasis. Advances in the understanding of mechanisms and the treatment efficacy will be reflected. We hope that the readers will enjoy reading the broad range of papers published in this issue, including meta-analysis of TCM treatment efficiency on tumor patients, the research articles on the anti-tumor mechanism and reviews on the recent advances of anti-tumor effects of TCM, as well as brief communications on the clinical therapies.

Meta-analysis is an effective approach in the studies on TCM treatment efficiency and is increasing in recent years. [5] Indeed, there are several articles on meta-analysis in this issue. Chen et al. evaluated the clinical efficacy of elements intrapleural injection in the treatment of lung cancer with malignant pleural effusion by meta-analysis. Kanglaite (KLT) injection is used to treat primary nonsmall cell lung cancer (NSCLC) and primary hepatocellular carcinoma (HCC), two articles in this issue focused on KLT and revealed its efficacy in anti-tumor: Fu et al. analyzed KLT injection combined with hepatic arterial intervention for the treatment of unresectable HCC. Meanwhile, the paper by Liu et al. appraised the clinical efficacy of KLT injection combined with chemotherapy and chemotherapy alone in the treatment of advanced NSCLC. Many TCM are applied in combination with chemotherapy for the treatment of tumor. As such, Li et al. revealed clinical value of Fufang Kushen injection in the treatment of gastric cancer by meta-analysis. Yao et al. indicated Shenqi Fuzheng (SQFZ) injection combined with chemotherapy more efficient to improve advanced gastric cancer than chemotherapy alone. Moreover, retrospective study by Wang et al. revealed the clinical value of Aidi injection combined with FOLFOX4 chemotherapy in the treatment of advanced colorectal cancer. Meta-analysis by Wu et al. demonstrated that patients with advanced HCC, who were treated with cinobufacini combined with transcatheter arterial chemoembolization could obtain increased response rate and 2 years survival rate.

Meta-analysis provides insights and methods to test the function and efficacy of TCM, and also provides help for the understanding of mechanisms. As for the anti-tumor mechanisms of TCM, it is also the highlights of this issue. Qiu et al. concluded the anti-tumor molecular mechanisms used by TCM, demonstrating that TCM treatment on tumors exhibits multi-target spots and multi-efficacy effects. While Li et al. focused on anti-tumor metastasis mechanisms of TCM. Moreover, Song et al. and Zhang et al. overviewed the anti-tumor effects of two TCM extracts, amygdalin, and triterpene acid compounds, respectively, highlighting the anti-tumor activities and mechanisms, both providing new insight into further investigations. Although numerous studies focused on natural products, it is relatively weak in TCM-related research due to the complexity and diversity of TCM. [6] Further investigations and more efforts are still needed to promote the development. To support this view, Qi et al. in this issue, carried out a bibliometric research on the "natural products against cancer" related studies, revealing that TCM was one of the major research topics and more investigations were needed to fill the gap between basic research and drug discovery. Meanwhile, the current issue also includes a research article from Zhang et al., they investigated the mechanism and anti-tumor effect of Shaoyao Ruangan Formula (SRF) in HCC, indicating that SRF showed tumor-repressing effect on H22-bearing mice and probably by up-regulating transforming growth factor beta receptor type II and down-regulating nuclear factor-kappaB. All these revealed significant anti-tumor effect of TCM. Up to now, there are many TCM entered into clinical trials, presenting remarkable efficacy. [3] Herein, there are two brief communication articles, focusing on anti-tumor effect of sodium cantharidinate/Vitamin B6. Shao et al. carried out the clinical trials through applied sodium cantharidinate/Vitamin B6 as an adjuvant drug in the treatment of the patient with middle/late stage primary liver cancer. And Wang et al. also utilized sodium cantharidinate/Vitamin B6/GP regimen in clinic mid-late stage NSCLC. Both of the two clinical trials obtained success, suggesting the effectiveness and synergistically of cantharidinate/Vitamin B6 in improving clinical outcomes.

Together, we hope these contributions will provide new insights and grounds for tremendous optimism for the readers. We also anticipate that the exciting results in this highly active research field will not only provide detailed understanding of anti-tumor mechanisms of TCM, but also more importantly pave the way to novel and effective therapies.

 > References Top

1.Luo F, Gu J, Chen L, Xu X. Systems pharmacology strategies for anticancer drug discovery based on natural products. Molecular bioSystems 2014;10:1912-7.  Back to cited text no. 1
2.Yang J, Zhu L, Wu Z, Wang Y. Chinese herbal medicines for induction of remission in advanced or late gastric cancer. The Cochrane database of systematic reviews 2013;4:Cd005096.  Back to cited text no. 2
3.You L, An R, Liang K, Wang X. Anti-breast cancer agents from Chinese herbal medicines. Mini reviews in medicinal chemistry 2013;13:101-5.  Back to cited text no. 3
4.Qi F, Li A, Inagaki Y, Gao J, Li J, Kokudo N, et al. Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer. Bioscience trends 2010;4:297-307.  Back to cited text no. 4
5.Yanju B, Yang L, Hua B, Hou W, Shi Z, Li W, et al. A systematic review and meta-analysis on the use of traditional Chinese medicine compound kushen injection for bone cancer pain. Supportive care in cancer: Official journal of the Multinational Association of Supportive Care in Cancer 2014;22:825-36.  Back to cited text no. 5
6.Lu JJ, Pan W, Hu YJ, Wang YT. Multi-target drugs: The trend of drug research and development. PloS one 2012;7:e40262.  Back to cited text no. 6


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