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Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 437-439

Merkel cell carcinoma-A rare primary neuroendocrine skin tumor: Case report and discussion

1 Department of Radiation Oncology, Grecian Superspeciality Hospital, Sector 69, Mohali, Punjab, India
2 Department of Surgery, Grecian Superspeciality Hospital, Sector 69, Mohali, Punjab, India
3 Department of Pathology, Grecian Superspeciality Hospital, Sector 69, Mohali, Punjab, India

Correspondence Address:
Nidhi Gupta
G-427, GH-2, Shikhar Apartments, Mansa Devi Complex, Sector 5, Panchkula, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.136683

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Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous primary small cell carcinoma with an unfavorable prognosis. It is a disease of the sun exposed skin of the elderly commonly involving the head, neck, and extremities. Though most cases present as localized disease, treatment should be definitive with wide excision of the primary lesion (2-3 cm margin) and prophylactic lymphadenectomy followed by irradiation to the primary site. Even when locoregional control is achieved, close surveillance is required due to high rates of local and systemic relapses. Chemotherapy is preserved for systemic disease, though the success of this treatment is limited and no chemotherapy protocol has been shown to improve survival.

Abstract in Chinese

默克尔细胞癌-----一种罕见的原发性神经内分泌肿瘤:病例报告与讨论 摘要 默克尔细胞癌(MCC)是一种罕见但侵袭皮肤的原发性小细胞癌,预后不良。它是皮肤受阳光照射而发生于老年人常见的皮肤病,主要位于头部,颈部和四肢。虽然大多数病例表现为局限性疾病,治疗应予明确的原发病灶广泛切除术(2~3cm距病灶边缘),预防性淋巴结清扫术,并随后在原发部位放疗。即使局部区域得到控制,仍需要严密监视,因为有较高的局部和全身复发率。化疗可用于全身性疾病,虽然治疗的成功率是有限的,尚无化疗方案已被证明能提高生存率。

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