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Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 377-380

Primary Ewing's sarcoma of the cranium: Case series and review of literature

1 Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, India
2 Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, India

Correspondence Address:
Kalpathi Krishnamani
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad - 500 082
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.136663

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Primary Ewing's sarcoma (EWS) of the cranium is extremely rare. It accounts for <1% of cases. We retrospectively analyzed our EWS cases to determine those which had a primary cranial involvement. Out of a total of 332 cases of EWS registered between the years 2000 and 2011, 7 were of the primary cranial involvement. Treatment modalities included surgery, chemotherapy, and radiotherapy (RT), as indicated. The follow-up ranged from 8 months to 7.5 years. In our study, parieto-occipital region was the commonest site. Most patients presented with localized disease and swelling of the scalp. Excision followed by chemotherapy or RT appears to have good survival rates. At a median follow-up of 32.2 months, only one patient had a recurrence, and was successfully salvaged with second line chemotherapy. These cases illustrate that a multi-disciplinary approach in patients with EWS of the cranium results in a good outcome.

Abstract in Chinese

颅骨原发性尤文氏肉瘤病例及文献回顾 摘要 头骨的原发性尤文氏肉瘤(EWS)是极为罕见的。它占<1%的病例。本文回顾性分析了我们的原发于颅骨的EWS病例。2000和2011年间登记的EWS共332例,7例原发颅骨受累。治疗方式包括手术,化疗,放疗(RT)。随访8个月~7.5年。在我们的研究中,顶枕区是最常见的部位。绝大多数患者表现为局部病灶和头皮肿胀。化疗或放疗后切除似乎有良好的生存率。中位随访32.2月,只有一个病人复发,并被二线化疗成功挽救。这些情况说明,多学科联合治疗有助于颅骨EWS患者治疗。 关键词:化疗,颅骨,尤文氏肉瘤

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