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Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 365-367

Generalized vitiligo post radiotherapy in a breast cancer patient

1 Department of Radiation Oncology, Krishna Institute of Medical Sciences, Secunderabad, Andhra Pradesh, India
2 Department of Radiotherapy and Oncology, Kasturba Medical College, Manipal, Karnataka, India

Correspondence Address:
Gangadhar Vajrala
11-3-148, Road No 13, S V Colony, Saroornagar, Hyderabad-500 035, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.136659

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Vitiligo is a common depigmentation disorder of skin, etiology of which is poorly understood. It has been rarely reported as a consequence of radiation at the site of irradiation, more so in patients with prior history of vitiligo. We report a rare clinical vignette that documents radiation-induced skin depigmentation, which started at the irradiated site and later manifested as generalized vitiligo, in a breast cancer patient with no family history of vitiligo. Studies describing the relationship between skin depigmentation and radiotherapeutic dose are scanty. The possible etiopathological mechanisms of vitiligo and radiation as a potential triggering factor for its development, which has been described in the literature, have been highlighted in this article.

Abstract in Chinese

乳腺癌患者放疗后泛发性白癜风 摘要 白癜风是一种常见的皮肤色素脱失性疾病,其病因是知之甚少。因放射引起的放射部位白癜风已很少报道,尤其是本就有白癜风病史的患者。我们报告一个罕见的临床案例,该患者是一个没有白癜风家族史的乳腺癌患者,因为放疗引起的皮肤色素脱失,开始在照射部位,后期表现为泛发性白癜风。描述的皮肤色素脱失和放射治疗剂量之间的关系的研究是不足的。白癜风和辐射的可能发生机制作为一种潜在的触发因素的发展,这已被描述在文献中,并在本文中进一步强调。 关键词:乳腺癌,放射治疗,白癜风,色素脱失

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