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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 324-329

Resveratrol successfully treats experimental endometriosis through modulation of oxidative stress and lipid peroxidation


1 Department of Obstetrics and Gynecology, Inonu University Faculty of Medicine, Malatya, Turkey
2 Department of Pathology, Inonu University Faculty of Medicine, Malatya, Turkey
3 Department of Biochemistry, Inonu University Faculty of Medicine, Malatya, Turkey

Correspondence Address:
Simsek Yavuz
Department of Obstetrics and Gynecology, Inonu University Faculty of Medicine, Malatya
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.136619

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Background and Aims: The purpose of this study was to investigate the potential therapeutic efficiency of resveratrol in the treatment of experimental endometriosis in rats. Settings and Design: Experimental study was carried out in a University hospital. Materials and Methods: Endometriosis was surgically induced in 24 female rats. Four weeks after this procedure, the viability and dimensions of the endometriosis foci were recorded. Rats were then randomly divided into three groups: (1) Control group (n = 8); (2) low dose (10 mg/kg) resveratrol group (n = 8); (3) high dose (100 mg/kg) resveratrol group (n = 8). At the end of the 7-day treatment, blood samples were taken and laparotomy was performed. The endometrial implants were processed for biochemical, histological and immunohistochemical studies. Statistical Analysis Used: The Kruskal-Wallis H test and one-way ANOVA test were used. Results: Resveratrol-treated rats showed significantly reduced endometriotic implant volumes (P = 0.004). After treatment, a significant and dose-dependent increase in activities of superoxide dismutase and glutathione peroxidase in serum and tissue of the rats in Group 2 and Group 3 was detected. Similarly, serum and tissue malonyl dialdehyde levels and tissue catalase levels were significantly higher in Group 3 than that of control animals. Histological scores and proliferating cell nuclear antigen expression levels were also significantly reduced in Group 2 and Group 3 than that of control group. Conclusion: In a rat endometriosis model, resveratrol showed potential ameliorative effects on endometriotic implants probably due to its potent antioxidative properties.

Abstract in Chinese

白藜芦醇成功治疗实验性子宫内膜异位症:通过调节氧化应激和脂质过氧化影响 摘要 背景与目的:本研究的目的是探讨在治疗大鼠实验性子宫内膜异位症,白藜芦醇的潜在的治疗效果。 设置和设计:实验研究是在某所大学医院进行。 材料与方法:雌性大鼠手术诱导建立子宫内膜异位症模型,四周后记录子宫内膜异位灶的活力和尺寸。24只大鼠随机分为三组:(1)对照组(n=8);(2)低剂量(10mg/kg)白藜芦醇组(n = 8);(3)高剂量(100mg/kg)白藜芦醇组(n = 8)。给药7天后,收集血液样本并进行剖腹探查术。对子宫内膜植入物进行生化,组织学和免疫组织化学研究。 统计分析采用Kruskal沃利斯检验和单因素方差分析法。 结果:白藜芦醇治疗组大鼠子宫内膜异位植入物体积明显小于对照组(P = 0.004)。治疗组血清中超氧化物歧化酶和谷胱甘肽过氧化物酶的活性明显增高,而且治疗组血清和组织丙二醛水平和组织过氧化氢酶含量显著高于对照组的动物。治疗组比对照组的组织学评分和增殖细胞核抗原的表达水平也显着减少。 结论:白藜芦醇对子宫内膜异位症模型大鼠的潜在改善效果可能是由于其强大的抗氧化性能。 关键词:子宫内膜异位症,氧化应激,白藜芦醇,治疗



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