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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 305-308

Utility of the trough plasma imatinib level monitoring at two time points in patients with the chronic myeloid leukemia-chronic phase


1 Department of Hematology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Ocular Pharmacology and Pharmacy, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Tulika Seth
Department of Hematology, All India Institute of Medical Sciences, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.136583

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Introduction: Plasma imatinib levels vary widely in patients with the chronic myeloid leukemia-chronic phase, and studies have shown improved hematological, cytogenetic, and molecular responses in patients with the higher trough imatinib levels. Materials and Methods: We analyzed 50 consecutive patients with the chronic myeloid leukemia-chronic phase and performed plasma imatinib levels at 1 month and 12 months and correlated them with complete hematological response at 3 months and molecular response at 12 months, respectively. Results: Trough plasma imatinib levels at 1 month correlated well with complete hematological response at 3 months (P = 0.007) and levels at 12 months correlated with molecular response at 12 months (P = 0.04). Compliance to imatinib also significantly correlated with imatinib levels at 1 month (P = 0.0008) and imatinib levels at 12 months (P = 0.0002). Conclusion: Plasma imatinib levels may be of benefit in patients not achieving desired response at defined time intervals. The plasma level monitoring also helps in the assessment of drug compliance.

Abstract in Chinese

慢性粒细胞白血病患者慢性期的波谷血浆伊马替尼水平在两个时间点监测的效用评价 摘要 简介:血浆伊马替尼水平在慢性粒细胞白血病慢性期患者中差别很大。研究表明,较高波谷伊马替尼水平患者具有较好的血液,细胞遗传学和分子反应。 材料和方法:监测50例慢性粒细胞白血病慢性期患者1个月和12个月的血浆,分析其与3个月时完整的血液学反应和12个月时分子反应的关系。 结果:血浆波谷伊马替尼水平在1个月与3个月完全血液学反应相关性很高(P = 0.007),12个月水平与12个月的分子反应水平相关性也极好(P = 0.04)。依从性与伊马替尼水平相关性也极好,1个月(P = 0.0008)12个月(P = 0.0002)。 结论:对于严格按照时间间隔服药而没有达到预期效果的病人,监测血浆伊马替尼水平可能有帮助。血浆水平的监测也有助于服药依从性的评价。 关键词:慢性粒细胞白血病;依从性;分子反应;波谷血浆伊马替尼水平



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