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Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 62-67

Amelioration of doxorubicin induced cardio-and hepato-toxicity by carotenoids

Department of Radiation Biology, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala, India

Correspondence Address:
Cherupally Krishnan Krishnan Nair
Dean of Research, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla - 689 101, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.131370

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Aim of Study: The aim of this study is to explore the ability of the carotenoids (CARs) to offer protection against acute cardiotoxicity and hepatotoxicity induced by doxorubicin (DOX) (25 mg/kg) in tumor bearing Swiss albino mice. Materials and Methods: Tumor bearing Swiss albino mice administered with DOX (25 mg/kg, i.p) and two doses of CARs (50 and 100 μg/kg). 24 h after administration of the drugs, histopathological evaluation of tumor, liver and heart tissues carried out. Furthermore, various antioxidant parameters in these tissues were investigated. Serum marker enzymes for tissue injury were examined. Results: Administration of CARs prevented the depletion of antioxidants in the heart and liver, thereby protecting the tissue damage and release of marker enzymes. However, similar antioxidant depletion was not observed in the tumor tissue. CARs prevented DOX induced variation in tissue architecture in heart and liver tissues. However, CARs did not influence DOX induced alterations in the tumor. Conclusion: Administration of CARs could prevent DOX induced acute toxicity to heart and liver.

Abstract in Chinese

类葫萝卜素改善多柔比星引起心脏毒性和肝毒性 研究目的:本文旨在研究发现类葫萝卜素(CARs)对抗多柔比星(DOX)(25mg/kg)治疗荷瘤瑞士白化小鼠引起的心脏毒性和肝毒性的作用。 材料和方法:荷瘤瑞士白化小鼠被注射多柔比星(25mg/kg,腹腔内注射),并予两个不同剂量的类葫萝卜素(50、100μg/kg)。注药后24小时,对瘤体、肝脏、心脏组织的组织病理学进行评估。此外,这些组织中的多种抗氧化指标也被研究。血清的组织损伤标记酶也被检测。 结果:类葫萝卜素阻止了心脏和肝脏抗氧化剂的消耗,因此减少了组织损伤和标记酶的释放。然而,类似的抗氧化剂耗尽在肿瘤组织中并未观察到。类葫萝卜素阻止了多柔比星引起的心脏和肝脏组织结构变异,而不影响肿瘤组织的改变。 结论:注射类葫萝卜素可以预防多柔比星引起的心脏和肝脏急性毒性。 关键词:抗氧化指标,心脏毒性,类葫萝卜素,多柔比星,肝脏毒性

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