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Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 207

Pathological features of primary mediastinal neuroendocrine carcinoma

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Date of Web Publication23-Apr-2014

Correspondence Address:
Shashikant C.U. Patne
Department of Pathology, IMS, BHU, Varanasi - 221 005, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.131421

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How to cite this article:
Patne SC, Shukla J. Pathological features of primary mediastinal neuroendocrine carcinoma. J Can Res Ther 2014;10:207

How to cite this URL:
Patne SC, Shukla J. Pathological features of primary mediastinal neuroendocrine carcinoma. J Can Res Ther [serial online] 2014 [cited 2021 Jul 28];10:207. Available from: https://www.cancerjournal.net/text.asp?2014/10/1/207/131421


We read with interest the article titled "Primary neuroendocrine mediastinal tumour presenting with carcinoid syndrome and left supraclavicular lymphadenopathy: Clinico-radiological and pathological features" by Dwivedi et al., published in April-June 2013 issue volume 2 pages 278-280. Authors have thoroughly described clinical and radiological findings in a rare case of the mediastinal neuroendocrine tumour in a young male patient. However, we feel that pathological features of the tumour have not been sufficiently described. Grossly, mediastinal neuroendocrine carcinomas are 2-cm to 20-cm in size and show homogenous and rubbery cut surface with foci of haemorrhage and necrosis. [1] Although contrast enhanced CT scan findings of the mediastinal mass have been well written, the gross and microscopic features of radical surgery specimen have not been documented at all. It would be interesting to know about size and grade of the tumour, presence of thymus tissue, presence of necrosis, vascular invasion and immunohistochemical profile of the tumour removed by radical surgery with photographic illustration. Histopathological grading in a neuroendocrine tumour is very important for accurate diagnosis as well as for determining prognosis. Based on mitotic count, nuclear atypia and presence of necrosis, neuroendocrine carcinomas are divided into low grade, intermediate grade and high grade. [1] Authors themselves have agreed that histopathological and immunohistochemical confirmation is mandatory in such cases. Despite this, important histopathological findings such as mitotic count, nuclear atypia, presence of necrosis and vascular invasion in this published case have not been mentioned. Further, neuroendocrine carcinomas are positive for synaptophysin and/or chromogranin, however, positive immunohisotchemical study for creatinine kinase was a surprising finding. Extensive search of the published literature did not show creatinine kinase positivity in neuroendocrine carcinomas. Finally, we feel that a pathologist should be included as author in such papers where pathological features are described. This practice will ensure dissemination of essential and appropriate information of pathology to the readers.

 > References Top

1.Moran CA, Suster S. Neuroendocrine carcinomas (carcinoid tumor) of the thymus: A clinicopathologic analysis of 80 cases. Am J Clin Pathol 2000;114:100-10.  Back to cited text no. 1


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