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Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 200-202

Primary intracranial benign fibrous histiocytoma: Report of an unusual case

1 Department of Pathology, Armed Forces Medical College, Pune, India
2 Department of Neurosurgery, Command Hospital, Pune, India
3 Department of Radiology, Armed Forces Medical College, Pune, India

Correspondence Address:
Prabal Deb
Department of Pathology, Armed Forces Medical College, Pune
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.131417

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Benign fibrous histiocytomas (BFH) are neoplasms of the soft tissue and bone composed of fibroblastic and histiocytic components without any nuclear pleomorphism or histological anapalsia. Primary intracranial fibrous histiocytomas are rare entities. In comparison with the malignant counterpart, BFH are more uncommon. We describe a case of a 54-year-old woman, who presented with complaints of headache, giddiness, and gait instability of six months' duration. Magnetic resonance imaging (MRI) studies revealed an extra-axial lesion in the inferior aspect of the left temporal lobe suggestive of en-plaque meningioma. Subsequent histopathological examination of the biopsy sample revealed a benign fibrous histiocytoma, with involvement of the overlying temporal bone. Immunohistochemical analysis showed positivity for vimentin and CD68, with MIB-1 labeling index (MIB-1LI) of 2%, confirming the diagnosis.

Abstract in Chinese

原发性颅内良性纤维组织细胞瘤:一例罕见病例报告 良性纤维组织细胞瘤(BFH)是发生于软组织和骨的,由成纤维细胞和组织细胞成分组成但无核多形性或组织学间变的肿瘤。颅内原发性纤维组织细胞瘤是一种罕见的肿瘤。与其对应的恶性肿瘤相比,良性纤维组织细胞瘤更少见。我们描述了一个54岁的女人,主诉持续6个月的头痛,头晕和步态不稳。磁共振成像(MRI)的研究显示,一个轴外病变在左颞叶下部提示脑膜瘤。随后的活检标本的病理检查显示良性纤维组织细胞瘤,上颞骨受累。免疫组化分析表明,波形蛋白和CD68阳性,MIB 1标记指数(MIB 1LI)2%,诊断明确。 关键词:良性,硬脑膜,纤维性的,组织细胞瘤,脑膜瘤

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