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Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 191-193

Lambda light chain myeloma presenting as nodular hepatic lesion: A clinical rarity

1 Department of Radiotherapy, Medical College and Hospitals, Kolkata, India
2 Department of General Medicine, Nilratan Sircar Medical College and Hospital, Kolkata, India

Correspondence Address:
Bitoti Chattopadhyay
Flat 2G, Nature's Nest, 140, Prince Gulam Hussain Shah Road, Jadavpur, Kolkata - 700 032
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.131409

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We report a case of a 63-year-old lady presenting with pain in the right hypochondrium, jaundice, anorexia, and firm tender hepatomegaly with remarkably high serum alkaline phosphatase. Abdominal ultrasonography revealed a hypoechoic solid space-occupying lesion in right lobe of liver which was cytologically diagnosed as hepatic plasmacytoma. Serum and urine immunofixation electrophoresis, serum free light chain ratio, and bone marrow examination further confirmed the presence of lambda light chain multiple myeloma in the background. The patient achieved complete remission after four cycles of induction therapy with thalidomide and dexamethasone protocol and consolidated with further four cycles of the same regimen.

Abstract in Chinese

λ轻链多发性骨髓瘤表现为结节性肝损害:一个临床罕见病例 我们报告一个63岁的女性出现在右季肋部疼痛,黄疸,厌食症,确定的难治性肝肿大,具有非常高的血清碱性磷酸酶。腹部超声显示肝脏右叶低回声实性占位病变,细胞学诊断为肝浆细胞瘤。血清和尿免疫固定电泳,血清游离轻链比值和骨髓检查进一步证实了λ轻链型多发性骨髓瘤的存在。病人在4个周期的沙利度胺和地塞米松方案诱导治疗后达到完全缓解,再以相同方案巩固治疗4个周期。 关键词:肝浆细胞瘤,λ轻链,多发性骨髓瘤

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