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Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 171-175

Risk factors, lipid profile, and histopathological study of oral cancers in Kolar district: A case-control study

1 Department of Biochemistry, Sri Devaraj Urs Medical, College, Tamaka, Kolar, Karnataka, India
2 Department of Pathology, Sri Devaraj Urs Medical, College, Tamaka, Kolar, Karnataka, India
3 Department of Otorhinolaryngology, Sri Devaraj Urs Medical, College, Tamaka, Kolar, Karnataka, India

Correspondence Address:
Hemalatha Anantharamaiah
Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar - 563 101, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.131456

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Aims: To estimate serum lipid profile in oral squamous cell carcinoma and correlate the risk factors and lipid profile with oral squamous cell carcinoma. Materials and Methods: Lipid profile was done in agriculturists/laborers in the age group of 30-70 years; 56 subjects (cases = 28, control = 28) were included. Study was carried out for a duration of four months; statistical analyses applied were mean, standard deviation, and independent 't' test. P < 0.05 was considered statistically significant. Results: Eleven cases had buccal mucosa cancer, nine had tongue carcinoma, and eight had gingivobuccal sulcus carcinoma. Lipid profile such as total cholesterol, triglycerides, LDL cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, and very-low-density lipoprotein (VLDL) were marginally and slightly elevated in cases compared to controls. HDL was grossly decreased in cases compared to controls. Conclusions: There was a significant association between HDL and squamous cell carcinoma; maximum number of SCC had a history of smoking in the range of 10-19 years, irrespective of other lipid parameters, constrained to the fact that lipids are genetically determined, have geographical variation, and are highly skewed.

Abstract in Chinese

科拉尔区口腔癌的危险因素,血脂谱,组织病理学研究:病例对照研究 目的:评价在口腔鳞状细胞癌患者血清血脂谱,关联口腔鳞状细胞癌的危险因素与血脂谱。 材料和方法:研究30~70岁年龄组的农民/工人血脂谱;共56个受试者(病例= 28,对照=28)。研究了4个月的时间进行了统计分析;应用进行平均,标准偏差,和独立的t检验法。P<0.05有统计学意义。 结果:11例颊黏膜癌,9例舌癌,8例龈颊沟癌。血脂如胆固醇,甘油三酯,低密度脂蛋白胆固醇,非高密度脂蛋白胆固醇(非高密度脂蛋白),以及极低密度脂蛋白(VLDL)略有升高,与对照组比较。高密度脂蛋白与对照组相比HDL严重下降。 结论:HDL和鳞状细胞癌有显著关联;绝大多数鳞状细胞癌患者有10~19年吸烟史,不论其他血脂参数,事实是脂类是由基因决定的,有地理变异和高度偏离。 关键词:组织病理学,血脂谱,口腔鳞状细胞癌,下降的高密度脂蛋白

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