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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 153-158

Dosimetric comparison of vaginal vault ovoid brachytherapy versus intensity-modulated radiation therapy plans in postoperative patients of cervical carcinoma following whole pelvic radiotherapy


Department of Radiotherapy and Oncology, Regional Cancer Centre, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India

Correspondence Address:
Divya Khosla
Department of Radiotherapy and Oncology, Regional Cancer Centre, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.131449

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Introduction: Dosimetric study to compare high dose rate (HDR) vaginal vault ovoid brachytherapy plan versus intensity-modulated radiation therapy (IMRT) boost plan for doses delivered to target volume and organs at risk (OAR) in postoperative patients of cervical carcinoma following whole pelvic radiotherapy (WPRT). Materials and Methods: Fifteen postoperative patients of cervical carcinoma suitable for vaginal ovoid brachytherapy following WPRT of 46 Gy/23 fractions/4.5 weeks were included. All were treated with brachytherapy (two sessions of 8.5 Gy each). The equivalent dose for IMRT was calculated by computing biologically effective dose of brachytherapy by linear quadratic model. Dose of brachytherapy (two sessions of 8.5 Gy) was equivalent to IMRT dose of 26 Gy/13 fractions. Doses to target volume and OAR were compared between HDR and IMRT plans. Results: Target volume was well covered with both HDR and IMRT plans, but dose with brachytherapy was much higher (P < 0.05). Mean doses, doses to 0.1, 1, 2, and 5cc, 1/3 rd , 1/2, and 2/3 rd volume of bladder and rectum were significantly lower with HDR plans. Conclusion: In postoperative patients of cervical carcinoma, HDR brachytherapy following WPRT appears to be better than IMRT for tumor coverage and reducing dose to critical organs.

Abstract in Chinese

宫颈癌术后全盆腔放疗后阴道穹窿卵球形的近距离放射治疗与调强放射治疗计划的剂量学比较 引言:用剂量学研究比较宫颈癌术后全盆腔放疗(WPRT)后阴道穹窿卵球形的高剂量率(HDR)近距离放射治疗计划与调强放射治疗(IMRT)计划传递到靶区和危及器官(OAR)的剂量。 材料和方法:包含了15例宫颈癌术后病例,均适用全盆腔放疗(46Gy / 23F/ 4.5w)+阴道卵球形近距离放疗(每次8.5Gy,共2次)。通过线性二次模型计算近距离照射的生物有效剂量的调强放疗等效剂量。近距离照射的剂量(2次8.5Gy)相当于调强剂量的26Gy/ 13F。将近距离放疗和调强计划的靶区和危险器官的剂量进行比较。 结果:近距离放疗和调强放疗计划均很好地覆盖靶区,但(靶区内)近距离放疗剂量高出很多(P<0.05)。平均剂量,0.1、1、2和5cc,1/3,1/2,2/3体积的膀胱和直肠剂量在近距离放疗计划中明显降低。 结论:对宫颈癌患者术后,全盆腔放疗+HDR近距离放疗优于调强放疗,无论在肿瘤覆盖上还是危及器官剂量减少上。 关键词:宫颈癌,高剂量率,调强放射治疗,术后,阴道穹窿卵球形近距离放射治疗



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