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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 103-106

Immunohistochemical expression of syndecan-1 in oral dysplastic epithelium


1 Department of Oral Pathology, Al-Ameen Dental College, Bijapur, India
2 Department of Prosthodontics, S. Nijalingappa Institute of Dental Sciences, Gulbarga, India
3 Department of Oral Pathology, Pacific Dental College, Udaipur, India
4 Department of Periodontics, S. Nijalingappa Institute of Dental Sciences, Gulbarga, India
5 Department of Oral Pathology, SVS Institute of Dental Sciences, Mahboobnagar, India

Correspondence Address:
B Lakkam
Department of Oral Pathology, Al Ameen Dental College, Bijapur
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.131407

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Background: In stratified squamous epithelia, syndecan-1 is proposed to function as a cellto cell adhesion molecule, and plays an important role in regulation of cell growth and differentiation during the developmental process. Oral cancer is a disease with complex etiology, so biological behavior in carcinomas preceded by dysplastic states is difficult to assess and predict its prognosis. Hence, syndecan-1, a recently recognized tumor marker has been proved to be an eminent diagnostic and prognostic tool in assessing biological behavior of various potentially premalignant andmalignant lesions. Materials and Methods: The study group consisted of 40 specimens of premalignant stateand 10 specimens of normal mucosa.Thesections were stained withhematoxylin and eosin, andimmunohistochemicallyusing syndecan-1 a primary antibody and was observed under light microscope. Results: Expression decreased with the decreasing grades of dysplasia. Conclusion: Syndecan-1 can be efficiently used in early detection and diagnosis of oral carcinoma.

Abstract in Chinese

口腔异常增生上皮多配体蛋白聚糖1的免疫组化表达 背景:在分层鳞状上皮细胞中,多配体蛋白聚糖1是具有细胞间黏附功能的分子,并在细胞增长和分化发展过程中起重要的管理作用。口腔癌病因复杂,其生物学行为也难以评估,预后不易判断。因此,多配体蛋白聚糖1,最近发现的一种肿瘤标志物,在评估复杂多样的潜在的可能癌变的和已经癌变的组织中,被证实为一种特别的诊断和提示预后的工具。 材料和方法:研究收集了40例癌前病变的样品和10例正常黏膜样品。用苏木精和曙红染色固定,免疫组化法,在光学显微镜下观察到多配体蛋白聚糖1为首要的抗体。 结论:多配体蛋白聚糖1可有效地用于口腔癌的早期检测和诊断。 关键词:细胞黏附分子,人细胞间黏附分子,恶变,口腔上皮异型增生,鳞状细胞癌,多配体蛋白聚糖



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