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Year : 2013  |  Volume : 9  |  Issue : 4  |  Page : 672-679

Treatment and outcome in cancer cervix patients treated between 1979 and 1994: A single institutional experience

1 Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India
2 Gynae-Oncology Services, Tata Memorial Hospital, Mumbai, India
3 Department of Surgical Oncology, Bombay Hospital Institute of Medical Sciences, Mumbai, India

Correspondence Address:
Umesh Mahantshetty
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai - 12
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.126480

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Introduction: A retrospective review in patients with carcinoma cervix to evaluate the changes and trends in demographics, evolution of protocols, and outcome analysis over 16 years. Materials and Methods: This is a retrospective study of 6234 patients with carcinoma of the cervix treated with radical intent between 1979 and 1994. All the work-up, staging investigations, treatment details, radiation protocols, outcomes, and toxicities were noted, compiled, and analyzed. Results: With a mean age of 46 years (range: 18-90 years; median: 45 years), 669 (11%) patients were in stage Ib, 284 (5%) were in stage IIa, 1891 (30%) were in stage IIb, 69 (1%) were in stage IIIa, and 3321 (53%) were in stage IIIb. With a median follow-up of 68 months (57-79 months) for the entire group, there was no significant difference in the outcome of 953 patients with international federation of gynecology and obstetrics (FIGO) Ib-IIa treated after radical surgery, pre-operative radiation therapy (pre-op RT) + Sx or after radical radiation; their disease-free survival (DFS) was 60-62% at 8 years. In our series of 1891 patients with stage IIb and 3321 with stage IIIb, a respective DFS of 56% and 40% was achieved at 8 years. Conclusion: Over the last two decades, with the acquisition of newer facilities and inception of Joint Clinics, there has been a significant refinement in the treatment protocols and outcome. Improving radiation strategies to improve therapeutic ratio is the key to success.

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