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Year : 2013  |  Volume : 9  |  Issue : 2  |  Page : 287-289

Pregnancy and cavernous sinus syndrome in diffuse large B-cell lymphoma

1 Department of Gynaecology and Obstetrics, the First Affiliated Hospital of Soochow University, Suzhou, China
2 Department of Haematology, the First Affiliated Hospital of Soochow University, Suzhou, China
3 Department of Neurology, the First Affiliated Hospital of Soochow University; Institute of Neuroscience, Soochow University, Suzhou, Jiangsu, China

Correspondence Address:
Jian-Ming Hu
Department of Gynaecology and Obstetrics, Xiao-Wei Hu, Department of Neurology, The First Affiliated Hospital of Soochow University, No.188 Shizi Street, Suzhou
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.113388

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Diffuse large B-cell lymphoma (DLBCL) usually present with rapidly growing lymph nodes or extra-nodal masses. Central nerve system involvement and pregnancy are rare in DLBCL. Here, we report an unusual case of DLBCL with cavernous sinus syndrome during pregnancy. A 24-year-old woman presented cavernous sinus syndrome as the initial presentation during pregnancy. Magnetic resonance imaging (MRI) revealed enlargement of bilateral cavernous sinus. Tonsil and ovary biopsy indicated malignant lymphoma-DLBCL. Bone marrow smear showed infiltration by tumor cells. The case delivered a viable baby by cesarean section and then took chemotherapy of rituxan, cyclophosphamide, adriamycin, eldisine and dexamethasone. The disease deteriorated rapidly, especially after the pregnancy was terminated. Fortunately, a complete response was achieved after six cycles of chemotherapy. With the accumulation of clinical practice of such cases, we would be able to recognize minimal symptoms of DLBCL at the beginning and confirm the most suitable timing of the initiation of chemotherapy during pregnancy.

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