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ORIGINAL ARTICLE
Year : 2012  |  Volume : 8  |  Issue : 4  |  Page : 549-554

Cannabinoid receptor 2 is upregulated in melanoma


1 Department of Dermatology, Chinese People's Liberation Army General Hospital, Beijing, China
2 Department of Dermatology, The Affiliated Hospital of North China Coal Medical College, Tangshan, China
3 Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China

Correspondence Address:
Hua Zhao
Department of Dermatology, The General Hospital of the People's Liberation Army, Beijing - 100853
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.106534

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Aims: To investigate the expression of CB 2 in normal skin, pigmented nevus, and malignant melanoma; analyze its relation with genesis; and development of malignant melanoma. Materials and Methods: In our study, we detected the expression of CB 2 in 20 cases of melanoma, nevus tissue, and normal skin tissues, respectively, by using immunohistochemistry, in situ hybridization, and RT-PCR. Moreover, we investigated the localization and expression of CB 2 in human melanoma cell line A375 and human immortalized keratinocyte cell line HaCaT by using immunofluorescence and western blotting. Results: Our data revealed that CB 2 is unregulated in melanoma. Conclusions: CB 2 plays a role in the development of melanoma.


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