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ORIGINAL ARTICLE
Year : 2010  |  Volume : 6  |  Issue : 3  |  Page : 290-295

Usefulness of whole body FDG18 PET-CT imaging in comprehensive oncologic management - initial experience


1 Department of Radiation Oncology, Kailash Cancer Hospital & Research Institute, Vadodara, Gujarat, India
2 Department of Nuclear Medicine, Kailash Cancer Hospital & Research Institute, Vadodara, Gujarat, India
3 Department of Radiodiagnosis, Kailash Cancer Hospital & Research Institute, Vadodara, Gujarat, India
4 Department of Oncopathology, Kailash Cancer Hospital & Research Institute, Vadodara, Gujarat, India

Correspondence Address:
Ashish S Kumar
Quarter no 7, Muniseva Ashram post- Goraj, TA- Waghodia, Vadodara, Gujarat 391760
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.73362

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Aims: Retrospective analysis of outcome with PET-CT imaging used for various clinical situations. Materials and Methods: Whole body PET-CT scan of 29 patients was evaluated. In first group, PET-CT was used for response evaluation after curative radio-chemotherapy. In second group, PET-CT was used as an additional diagnostic tool. In third group, PET-CT was used for delineating target volume. For first and second group, uptake was recorded with respect to primary, regional and distant site of involvement and confirmed through PET-CT guided biopsies whenever required. For third group, hypermetabolic volume delineated on PET image was compared with gross target volume delineated on CT image. Results: In first group, 50 % (6/12) of the patients had distant systemic disease, 33% (4/12) had residual regional disease and 58% (7/12) had residual/recurrent local disease. In second group, 30% (3/10) patients had distant systemic disease on PET-CT where CT was inconclusive. 25% (4/10) had variable extent of disease involvement on PET-CT that changed the technique of radiotherapy treatment. In 20% (2/10) patients, PET-CT changed the sequence of treatment. In third group (n=7), PET delineated volume was significantly higher (10-50%) than CT delineated volume for local site but for regional targets the difference was <10%. Conclusions: With the initial use of FDG18 PET-CT imaging, we realized that rate of distant metastasis is much higher which usually remain unnoticed because of conventional approach of investigation. PET-CT imaging has potential to improve the method of conventional IMRT planning.


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