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Year : 2009  |  Volume : 5  |  Issue : 2  |  Page : 102-106

Results of combined modality treatment for nasopharyngeal cancer

1 Division of Clinical Oncology, Ipswich Hospital, United Kingdom
2 Division of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai - 400 036, India

Correspondence Address:
Ramachandran Venkitaraman
Consultant Clinical Oncologist, Ipswich Hospital NHS
United Kingdom
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.52798

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Context: Radiotherapy is the cornerstone of treatment in nasopharyngeal cancer (NPC); the addition of chemotherapy has shown improved results. Aims: To compare the results of concurrent chemoradiation with that of radiotherapy alone in NPC. Materials and Methods: One hundred and ninety consecutive NPC patients, without distant metastasis, who reported to the institute from January 1992 to December 2001, received external-beam radiation to 66 Gy in 33 fractions. Seventy-five of these patients received concurrent chemotherapy with cisplatin and 5-fluorouracil (5-FU) for four cycles. We compared the results of treatment in these two groups. Results: The 5-year disease-free survival rates were 40% and 60%, respectively, for patients who had radiotherapy alone and those who had chemoradiation (P = 0.002), while the median survival was 45 months and 60 months, respectively (P = 0.0028). Conclusion: A significant improvement in local control and survival was observed by the addition of concurrent chemotherapy with cisplatin and 5-FU to radical radiation in this nonrandomized study on patients with NPC.

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