|
 
 |
| CASE REPORT |
|
| Year : 2008 | Volume
: 4
| Issue : 4 | Page : 195-196 |
|
Primary lymphoma of the ovary
Tijani Elharroudi1, Nabil Ismaili2, Hassan Errihani2, Abdelouahed Jalil2
1 Department of Surgery, National Institute of Oncology, Rabat, Morocco
2 Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco
| Date of Web Publication | 1-Dec-2008 |
Correspondence Address:
Nabil Ismaili
Department of Medical Oncology, National Institute of Oncology, Rabat
Morocco
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-1482.44291
Involvement of the ovary by malignant lymphoma is a well-known late manifestation of disseminated nodal disease. Primary ovarian lymphoma is rare. We report a case of primary ovarian non-Hodgkin's lymphoma with bilateral involvement which was managed by surgery and chemotherapy. A 29-year-old woman was admitted with signs and symptoms suggestive of an ovarian cancer. Computed tomography revealed an abdominal tumor measuring 20 cm in diameter, without enlarged lymph nodes. The diagnosis of malignant lymphoma was established after bilateral adnexectomy and histological study of the excised tissue. The tumor was classified as a diffuse large B-cell lymphoma. The patient has been advised 8 cycles of standard CHOP regimen and is presently on treatment. She has now been without disease for 7 months after the surgery. According to previous reports the treatment principles and prognosis of primary ovarian lymphoma is the same as that of other nodal lymphomas. Keywords: Lymphoma, ovary, primary
How to cite this article:
Elharroudi T, Ismaili N, Errihani H, Jalil A. Primary lymphoma of the ovary. J Can Res Ther 2008;4:195-6 |
| > Introduction | |  |
Involvement of the ovary by malignant lymphoma is well known as a late manifestation of disseminated nodal disease, almost always of the non-Hodgkin's type. But primary ovarian lymphomas are unusual. [1] Primary ovarian non-Hodgkin's lymphoma accounts for 0.5% of all non-Hodgkin's lymphomas and 1.5% of all ovarian neoplasms. [2] We present a case of ovarian non-Hodgkin's lymphoma, manifesting like ovarian cancer, which was managed by surgery and chemotherapy.
| > Case Report | | |
A 29-year-old woman (gravida 2, para 2) was admitted to our hospital with increasing abdominal volume, weight loss (12 kg), and extreme fatigue for 4 months. A physical examination revealed a mobile abdominopelvic mass reaching up to the epigastrium, mobile with regard to the deep and superficial plans. The pelvic exam and digital rectal examination were normal. The ganglionic areas were free from the disease. Computed tomography (CT) scan showed a heavily bilateral heterogeneous tissular abdominopelvic tumor, the largest one measuring 20 × 12 cm in diameter; there were no enlarged lymph nodes [Figure 1]. The serum tumor markers were positive, with CA-125 being 252 U/ml (normal < 25 U/ml). The erythrocyte sedimentation rate was increased, being 85 mm in the first hour and 105 mm in the second hour. An exploratory laparotomy was done through a large abdominal vertical midline incision so as to establish the diagnosis. Laparotomy revealed a left ovarian tumor measuring 28 × 11 cm in diameter [Figure 2] and a right ovarian mass measuring 7 cm, which was coarse, tissular, and without extracystic vegetations or ascetic fluid accumulation; there were no peritoneal implants, hepatic metastases, or adenomegaly. A bilateral adnexectomy with omentectomy, appendectomy, peritoneal cytology, and peritoneal biopsy were performed. The extemporaneous studyof the left ovarian tumor was not decisive. The histological study and immunohistochemistry were suggestive of a large B-cell non-Hodgkin's lymphoma in both the ovaries. Most of the neoplastic cells were positive for CD-20 and for leucocyte common antigen (LCA) antibody. Peritoneal cytology was positive. The rest of prelevements was negative. After surgery, CT of the chest, abdomen, and pelvis was normal and serum CA-125 was also normal. A bone marrow biopsy showed no abnormalities. The patient was staged IIE according to the Ann Arbor staging system. The patient was prescribed eight cycles of the standard CHOP regimen (cyclophosphamide 750 mg/m² d1, doxorubicin 50 mg/m² d1, vincristine 1.4 mg/m² d1, and prednisone 50 mg/m² d1-5); she has completed six cycles and, 7 months after surgery, she remains disease free.
| > Discussion | | |
Lymphoma is a rare tumor of the ovary and its presence most commonly represents involvement in overt systemic disease, almost always of the non-Hodgkin's type. [1] The diffuse, large B-cell lymphoma appears to be the most common type of primary ovarian non-Hodgkin's lymphoma. [2] There has been debate as to whether lymphoma can arise de novo in the ovary; lymphoid aggregates do exist in normal ovarian tissue, which could give rise to such lesions. [3] The majority of primary ovarian lymphomas present with pelvic complaints; some cases present with ascites and elevated serum CA-125. [4],[5] Our patient presented with a pelvic mass and elevated serum CA-125. The bilateral ovarian involvement, peritoneal implants, and omental involvement at the time of surgery may argue against a primary ovarian disease. [6] Our patient presented with bilateral ovarian involvement and positive peritoneal cytology. The presence of positive staining for leukocyte common antigen (LCA) in the histological specimen distinguishes malignant lymphoma from nonlymphoid neoplasm. [7] Diffuse, large B-cell lymphomas were positive for CD20 and BCL-6 and or CD-10 and or BCL-2. [5]
CT is the mainstay of lymphoma staging in the chest, abdomen, and pelvis as well as in other nodal lymphomas. Bone marrow biopsy is also mandatory for staging. Positron emission tomography (PET) with 18 F-fluorodeoxyglucose (FDG) has been reported as being a useful method for staging and for assessment of therapeutic response. [8]
Patients with disease localized to one ovary usually do well with unilateral surgical resection followed by systemic chemotherapy. [1] The use of chemotherapy is based on the principle that ovarian lymphoma must be considered a localized manifestation of systemic disease. [9] The prognosis for such patients is much better than that of patients with obvious systemic disease. [1] In primary ovarian lymphoma stages I-II, a conservative management based on exclusive chemotherapy may be attempted in selected patients desiring pregnancy. [10] The protocol of chemotherapy used in diffuse, large B-cell histology is the standard CHOP regimen. [2] Our patient was treated with bilateral adnexectomy, omentectomy, and appendectomy followed by eight cycles of CHOP. The outcome of these patients, treated with appropriate chemotherapy, appears to be similar to that of patients with other nodal non-Hodgkin's lymphomas. [2]
| > Conclusion | | |
Primary lymphoma of the ovary is rare. Its must be considered as a localized manifestation of systemic disease. According to the previous reports in literature, the treatment principles and the prognosis are the same as that of other nodal lymphomas.
| > Acknowledgment | | |
Mohammed Ismaili.
| > References | | |
| 1. | Monterrosso V, Jaffe ES, Merino MJ, Medeiros LJ. Malignant lymphomas involving the ovary: A clinicopathologic analysis of 39 cases. Am J Surg Pathol 1993;17:154-70. 
|
| 2. | Dimopoulos MA, Daliani D, Pugh W, Gershenson D, Cabanillas F, Sarris AH. Primary ovarian non-Hodgkin's lymphoma: Outcome after treatment with combination chemotherapy. Gynecol Oncol 1997;64:446-50.
|
| 3. | Woodruff JD, Noli Castillo RD, Novak ER. Lymphoma of the ovary: A study of 35 cases from the ovarien tumor registry of the American Gynecological Society. Am J Obstet Gynecol 1963;85:912-8.
|
| 4. | Perlman S, Ben-Arie A, Feldberg E, Hagay Z. Non-Hodgkin's lymphoma presenting as advanced ovarian cancer: A case report and review of literature. Int J Gynecol Cancer 2005;15:554-7.
|
| 5. | Vang R, Medeiros LJ, Warnke RA, Higgins JP, Deavers MT. Ovarian non-Hodgkin's lymphoma: A clinicopathologic study of eight primary cases. Mod Pathol 2001;14:1093-9.
|
| 6. | Yamada T, Iwao N, Kasamatsu H, Mori H. A case of malignant lymphoma of the ovary manifesting like an advanced ovarian cancer. Gynecol Oncol 2003;90:215-9.
|
| 7. | Yildirim Y. Primary ovarian large B-cell lymphoma in patient with juvenile rheumatoid arthritis treated with low dose Methotrexate. Gynecol Oncol 2005;97:249-52.
|
| 8. | Komoto D, Nishiyama Y, Yamamoto Y, Monden T, Sasakawa Y, Toyama Y, et al . A case of non-Hodgkin's lymphoma of the ovary: Usefulness of 18F-FDG PET for staging and assessment of the therapeutic response. Ann Nucl Med 2006;20:157-60.
|
| 9. | Fox H, Langley FA, Govan AD, Hill AS, Bennett MH. Malignant lymphoma presenting as ovarian tumor: A clinicopathologic analysis of 34 cases. Br J Obstet Gynaecol 1998;105:pg no missing.
|
| 10. | Signorelli M, Maneo A, Cammarota S, Isimbaldi G, Garcia Parra R, Perego P, et al . Conservative management in primary genital lymphomas: The role of chemotherapy Gynecol Oncol 2007;104:416-21.
|
[Figure 1], [Figure 2]
| This article has been cited by | | 1 |
Reproductive organ involvement in non-Hodgkin lymphoma during pregnancy: a systematic review |
|
| Netanel A Horowitz,Noam Benyamini,Kristina Wohlfart,Benjamin Brenner,Irit Avivi | | The Lancet Oncology. 2013; 14(7): e275 | | [Pubmed] | [DOI] | | | 2 |
Reproductive organ involvement in non-Hodgkin lymphoma during pregnancy: A systematic review |
|
| Horowitz, N.A. and Benyamini, N. and Wohlfart, K. and Brenner, B. and Avivi, I. | | The Lancet Oncology. 2013; 14(7): e275-e282 | | [Pubmed] | | | 3 |
Primary ovarian lymphoma - A rare entity |
|
| Afshan, A. and Sadaf, N. | | Journal of the Pakistan Medical Association. 2013; 63(4): 519-520 | | [Pubmed] | | | 4 |
Diffuse large B-cell lymphoma in the ovary: A case presentation [Linfoma B difuso de células grandes en ovario: presentación de un caso] |
|
| MartÃnez, M.A. and Hernández, N.A. and Avilés, R.S. and Reyes, E.A. and Molina, M.C. and Morales, M.G. | | Revista Chilena de Obstetricia y Ginecologia. 2013; 78(1): 64-67 | | [Pubmed] | | | 5 |
Initial presentation of plasmablastic lymphoma and ovarian tumor [Presentación inicial de un linfoma plasmablástico como tumor ovárico] |
|
| Avilés-Salas, A. and Chanona-Vilchis, J.G. and Candelaria-Hernández, M.G. and Peña-Torres, M.L. and Cuéllar-Mendoza, M.E. | | Ginecologia y Obstetricia de Mexico. 2012; 80(6): 430-434 | | [Pubmed] | | | 6 |
Möglichkeiten der Fertilitätsprotektion bei Lymphomen |
|
| B. Lawrenz, T. Fehm, S. Hübner, M. Henes | | Forum. 2012; | | [VIEW] | [DOI] | | | 7 |
Primary ovarian lymphoma in a child |
|
| Chakrabarti, B. and Bhaduri, B. and Barik, S. and Gupta, D. and Chakravorty, S. | | Journal of the Indian Medical Association. 2011; 109(9): 679-680 | | [Pubmed] | | | 8 |
To transplant or not to transplant - That is the question |
|
| Silber, S.J., Woodruff, T.K., Shea, L.D. | | Cancer Treatment and Research. 2010; 156: 41-54 | | [Pubmed] | | | 9 |
Primary lymphoma of the prostate treated with rituximab-based chemotherapy: A case report and review of the literature |
|
| Taleb, A., Ismaili, N., Belbaraka, R., Bensouda, A., Elghissassi, I., Elmesbahi, O., Droz, J.P., Errihani, H. | | Cases Journal. 2009; 2(8): art-8875 | | [Pubmed] | |
|
 |
|
|
|
Search Pubmed for