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Year : 2006  |  Volume : 2  |  Issue : 3  |  Page : 129-131

Diagnostic value of silver nitrate staining for nucleolar organizer regions in selected head and neck tumors

1 Department of OMF Pathology, Shaheed Beheshti School of Dentistry, Tehran, Iran
2 Basic Sciences Research Dept, Iran Center for Dental Research, Tehran, Iran
3 Pathology Dept, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Tabriz University of Medical Sciences, Tabriz, Iran
5 Iran Center for Medical Research, Tehran, Iran

Correspondence Address:
Hessam Rahimi
Iran Center for Dental Research, Shaheed Beheshti School of Dentistry, Evin, Tehran 19834
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.27588

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Background: The present study is aimed to assess the usefulness of silver nitrate staining of nucleolar organizer regions (NORs) as a quantitative criterion for the diagnosis of selected head and neck tumors. Materials and Methods: The silver nitrate staining technique was used on 195 paraffin blocks collected from 85 patients. The samples consisted of 21 squamous cell carcinoma (SCC) of larynx, 28 SCC of oral mucosa and 36 samples of most common salivary gland tumors. Mann-Whitney U-Test was used for data analysis. Results: A significant difference was seen in the number of AgNOR dots between oral and laryngeal SCC with surrounding dysplastic and normal tissues ( P < 0.001) and also between mucoepidermoid carcinoma and adenoid cystic carcinoma with pleomorphic adenoma and normal salivary gland tissue ( P < 0.001). Conclusion: The silver nitrate staining for NORs is a useful method for aiding the diagnosis of malignant and dysplastic mucosal lesions and also malignant and benign salivary gland tumors.

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