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ORIGINAL ARTICLE
Year : 2006  |  Volume : 2  |  Issue : 1  |  Page : 24-27

Brain tumor and role of β-carotene, a- tocopherol, superoxide dismutase and glutathione peroxidase


1 Department of Biochemistry, Maulana Azad Medical College, New Delhi, India
2 Deptt. of neurosurgery,G. B. Pant Hospital, New Delhi, India
3 Department of biochemistry and biotechnology National Institute of communicable diseases, New Delhi, India

Correspondence Address:
Manju Subberwal
146A/AG-1, Vikaspuri, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.19771

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The erythrocyte levels of the antioxidant enzymes SOD and GPx, and serum levels of antioxidants vitamins β -carotene and β -tocopherol were estimated in various types of brain tumors, and were compared with the levels in controls. Statistically significant (P<.001) diminished levels of β - carotene, β -tocopherol, SOD and GPx, were observed in all the brain tumor patients as compared to controls. Malignant tumor also showed a relative decrease in antioxidant levels as compared to benign tumors. Comparison of histopathological sections of brain tumors also suggested a inverse relationship between antioxidant level and grades of malignancy. Marked decrease in antioxidant levels may have a role in genesis of considerable oxidative stress in brain tumors. Further more, the degree of decline in antioxidant levels may indicate severity of malignancy in brain tumors.


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