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Figure 4: Decreased Rad51 and epithelial–mesenchymal transition process involves in radiosensitizing effects of berberine on osteosarcoma cells. MG-63 cells were treated with berberine (20 μM), irradiation (4 Gy), irradiation plus berberine, and irradiation plus B02 (50 μM) for 24 h. Protein levels of E-cadherin (a) and vimentin (b) were determined by western blot. The density of protein bands was converted into grayscale values and normalized to that of the internal control β-actin. Results are expressed as mean ± standard deviation. *P < 0.05 compared with control group.#P < 0.05 compared with irradiation alone group

Figure 4: Decreased Rad51 and epithelial–mesenchymal transition process involves in radiosensitizing effects of berberine on osteosarcoma cells. MG-63 cells were treated with berberine (20 μM), irradiation (4 Gy), irradiation plus berberine, and irradiation plus B02 (50 μM) for 24 h. Protein levels of E-cadherin (a) and vimentin (b) were determined by western blot. The density of protein bands was converted into grayscale values and normalized to that of the internal control β-actin. Results are expressed as mean ± standard deviation. *<i>P</i> < 0.05 compared with control group.<sup>#</sup><i>P</i> < 0.05 compared with irradiation alone group