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Figure 3: Berberine decreases Rad51 expression in enhanced radiosensitivity of osteosarcoma cells. MG-63 cells were treated with irradiation (4 Gy) and various concentrations of berberine (0, 20, 40, 60, and 80 μM) for 24 h. (a) Quantitative reverse transcription-polymerase chain reaction shows that berberine decreases Rad51 mRNA levels of MG-63 cells in a concentration-dependent manner. (b) Western blot shows that berberine decreases Rad51 protein levels in a concentration-dependent manner. (c) B02 enhances the radiosensitivity of MG-63 cells. *P < 0.05 compared with control group

Figure 3: Berberine decreases Rad51 expression in enhanced radiosensitivity of osteosarcoma cells. MG-63 cells were treated with irradiation (4 Gy) and various concentrations of berberine (0, 20, 40, 60, and 80 μM) for 24 h. (a) Quantitative reverse transcription-polymerase chain reaction shows that berberine decreases Rad51 mRNA levels of MG-63 cells in a concentration-dependent manner. (b) Western blot shows that berberine decreases Rad51 protein levels in a concentration-dependent manner. (c) B02 enhances the radiosensitivity of MG-63 cells. *<i>P</i> < 0.05 compared with control group