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Figure 2: Effects of berberine on cell cycle, apoptosis, and invasion of osteosarcoma cells. MG-63 cells were treated with γ-ray irradiation (4 Gy) and (or) berberine (20 μM) for 24 h. (a) Cell cycle analysis shows the percentages of cells in G0/G1, S and G2/M phases. *P < 0.05 (b) Berberine induces cell apoptosis, as detected by Annexin V/PI staining. (c) Berberine increases apoptotic rates in cells with irradiation. (d) Berberine inhibits invasion of MG-63 cells by the Boyden chamber assay. *P < 0.05 compared with control group.#P < 0.05 compared with irradiation alone group

Figure 2: Effects of berberine on cell cycle, apoptosis, and invasion of osteosarcoma cells. MG-63 cells were treated with γ-ray irradiation (4 Gy) and (or) berberine (20 μM) for 24 h. (a) Cell cycle analysis shows the percentages of cells in G0/G1, S and G2/M phases. *<i>P</i> < 0.05 (b) Berberine induces cell apoptosis, as detected by Annexin V/PI staining. (c) Berberine increases apoptotic rates in cells with irradiation. (d) Berberine inhibits invasion of MG-63 cells by the Boyden chamber assay. *<i>P</i> < 0.05 compared with control group.<sup>#</sup><i>P</i> < 0.05 compared with irradiation alone group