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Figure 3: Photomicrographs from Case 6 (diffuse large B-cell lymphoma with foci of extranodal marginal zone lymphoma) showing sheets of atypical small lymphoid cells infiltrating into the surrounding skeletal muscle (a; H and E, ×200). Foci of aggregates of interspersed large nucleated lymphoid cells are noted (b; H and E, ×400). On immunohistochemistry, the cells are positive for CD20 (c; ×200), BCL2 (d, ×400), and MUM1 (e, ×400); MIB-1 labeling index is high (f; ×400), while p53 is focally positive (g; ×400). Adjacent thyroid shows features of thyroiditis (h; H and E, ×200). Photomicrograph from Case 10 (diffuse large B-cell lymphoma) showing atypical large lymphoid cells with numerous mitoses (i; H and E, ×400)

Figure 3: Photomicrographs from Case 6 (diffuse large B-cell lymphoma with foci of extranodal marginal zone lymphoma) showing sheets of atypical small lymphoid cells infiltrating into the surrounding skeletal muscle (a; H and E, ×200). Foci of aggregates of interspersed large nucleated lymphoid cells are noted (b; H and E, ×400). On immunohistochemistry, the cells are positive for CD20 (c; ×200), BCL2 (d, ×400), and MUM1 (e, ×400); MIB-1 labeling index is high (f; ×400), while p53 is focally positive (g; ×400). Adjacent thyroid shows features of thyroiditis (h; H and E, ×200). Photomicrograph from Case 10 (diffuse large B-cell lymphoma) showing atypical large lymphoid cells with numerous mitoses (i; H and E, ×400)