Journal of Cancer Research and Therapeutics Close
 

Figure 7: Protein–protein interaction network generated by STRING version 10.0 online software. Two gene sets were used, that is, 8 tumor suppressor genes from the present study and 23 genes identified in a previous study of integration of epigenomic and transcriptomic data for esophageal squamous cell carcinoma. Figure shows the known, predicted, and other type of interactions. Network nodes represent proteins where splice isoforms or posttranslational modifications are collapsed, that is, each node represents all the proteins produced by a single, protein-coding gene locus. Edges represent protein–protein associations which are meant to be specific and meaningful, that is, proteins jointly contribute to a shared function. However, this does not necessarily mean they are physically binding each other. Small nodes are representing proteins of unknown three-dimensional structure while large nodes denote proteins with some three-dimensional structure is known or predicted

Figure 7: Protein–protein interaction network generated by STRING version 10.0 online software. Two gene sets were used, that is, 8 tumor suppressor genes from the present study and 23 genes identified in a previous study of integration of epigenomic and transcriptomic data for esophageal squamous cell carcinoma. Figure shows the known, predicted, and other type of interactions. Network nodes represent proteins where splice isoforms or posttranslational modifications are collapsed, that is, each node represents all the proteins produced by a single, protein-coding gene locus. Edges represent protein–protein associations which are meant to be specific and meaningful, that is, proteins jointly contribute to a shared function. However, this does not necessarily mean they are physically binding each other. Small nodes are representing proteins of unknown three-dimensional structure while large nodes denote proteins with some three-dimensional structure is known or predicted