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Figure 2: Enhanced presenilin 1 expression and increased activity of gamma-secretase in hepatocellular carcinoma cell lines. (a) One human liver cell line and five hepatocellular carcinoma cell lines were analyzed for the expression of presenilin 1 by Western blot. (b) The activities of gamma-cleavage in those cells were measured using a luciferase-based gamma-secretase reporter system. Data are presented as a percentage of activity where 100% activity corresponds to the reporter gene activity obtained in the BEL7404 cells. The graph shows mean ± standard deviation of three independent experiments

Figure 2: Enhanced presenilin 1 expression and increased activity of gamma-secretase in hepatocellular carcinoma cell lines. (a) One human liver cell line and five hepatocellular carcinoma cell lines were analyzed for the expression of presenilin 1 by Western blot. (b) The activities of gamma-cleavage in those cells were measured using a luciferase-based gamma-secretase reporter system. Data are presented as a percentage of activity where 100% activity corresponds to the reporter gene activity obtained in the BEL7404 cells. The graph shows mean ± standard deviation of three independent experiments