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Figure 2: Overexpression of miR-186 suppressed melanoma cell proliferation and caused cell-cycle arrest. (a) Ectopic expression of miR-186 in melanoma cell lines A375 and A875 were evidence by qRT-PCR after transfection of miRNA mimics. (b) Cell Counting Kit (CCK)-8 assays revealed cell growth curves of indicated cells. (c) Flow cytometric determination of proportion of indicated cells in distinct cell-cycle phases. *P < 0.05, **P < 0.01

Figure 2: Overexpression of miR-186 suppressed melanoma cell proliferation and caused cell-cycle arrest. (a) Ectopic expression of miR-186 in melanoma cell lines A375 and A875 were evidence by qRT-PCR after transfection of miRNA mimics. (b) Cell Counting Kit (CCK)-8 assays revealed cell growth curves of indicated cells. (c) Flow cytometric determination of proportion of indicated cells in distinct cell-cycle phases. *<i>P</i> < 0.05, **<i>P</i> < 0.01