Journal of Cancer Research and Therapeutics Close
 

Figure 4: The effects of different time sequences of administration of bevacizumab combined with 5-fluorouracil and cisplatin on the fluorescence signals of the nude mice. Group A: Bevacizumab + 5-fluorouracil and cisplatin chemotherapy contemporary, Group B: 5-fluorouracil and cisplatin chemotherapy for 24 h followed by bevacizumab, Group C: The bevacizumab treatment for 24 h followed by 5-fluorouracil and cisplatin chemotherapy, Group D: The bevacizumab treatment group, Group E: The control group with intraperitoneal injection of 1 ml normal saline. Tumour growth and distribution in the body were observed every 7 day. The tumour inhibition rates of five groups were calculated based on the tumour volume and reduction in the fluorescence signals of nude mouse tumours. Differences between the 2nd and the 3rd week after treatment in five groups all had statistical significance (P < 0.05). At the 1st and 2nd week, Group E had the highest signals, while the fluorescence signals ordered from low to high were Groups C, A, B, D, and E at the 3rd week. The fluorescence signals of the nude mouse tumours in Groups A and C at the 3rd week were dramatically lower than the rest before drug treatment (P < 0.05). The fluorescence signals of the nude mouse tumours in Group E showed a significant increasing trend over time (P < 0.05)

Figure 4: The effects of different time sequences of administration of bevacizumab combined with 5-fluorouracil and cisplatin on the fluorescence signals of the nude mice. Group A: Bevacizumab + 5-fluorouracil and cisplatin chemotherapy contemporary, Group B: 5-fluorouracil and cisplatin chemotherapy for 24 h followed by bevacizumab, Group C: The bevacizumab treatment for 24 h followed by 5-fluorouracil and cisplatin chemotherapy, Group D: The bevacizumab treatment group, Group E: The control group with intraperitoneal injection of 1 ml normal saline. Tumour growth and distribution in the body were observed every 7 day. The tumour inhibition rates of five groups were calculated based on the tumour volume and reduction in the fluorescence signals of nude mouse tumours. Differences between the 2<sup>nd</sup> and the 3<sup>rd</sup> week after treatment in five groups all had statistical significance (<i>P</i> < 0.05). At the 1<sup>st</sup> and 2<sup>nd</sup> week, Group E had the highest signals, while the fluorescence signals ordered from low to high were Groups C, A, B, D, and E at the 3<sup>rd</sup> week. The fluorescence signals of the nude mouse tumours in Groups A and C at the 3<sup>rd</sup> week were dramatically lower than the rest before drug treatment (<i>P</i> < 0.05). The fluorescence signals of the nude mouse tumours in Group E showed a significant increasing trend over time (<i>P</i> < 0.05)