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Figure 4e: Trial sequential analysis on secondary outcomes: Trial sequential analysis on the rate of skin irritation, involving 21 randomized controlled trials illustrated that the cumulative Z-curve had not crossed the monitoring boundary. The required information size was calculated to 26,534. (NOTE: The red line is the trial sequential analysis monitor boundary according to a relative risk reduction of 20%, type I error of 5% and type II error of 20%. The red horizontal line is the Z-score of ±1.96, equal to two-sided P = 0.05. X-axis: The number of patients randomized, Y-axis: the Z-score)

Figure 4e: Trial sequential analysis on secondary outcomes: Trial sequential analysis on the rate of skin irritation, involving 21 randomized controlled trials illustrated that the cumulative Z-curve had not crossed the monitoring boundary. The required information size was calculated to 26,534. (NOTE: The red line is the trial sequential analysis monitor boundary according to a relative risk reduction of 20%, type I error of 5% and type II error of 20%. The red horizontal line is the Z-score of ±1.96, equal to two-sided <i>P</i> = 0.05. X-axis: The number of patients randomized, Y-axis: the Z-score)