Journal of Cancer Research and Therapeutics Close
 

Figure 1: Survival curves and histogram showing IC50. (a) Metformin and ribavirin Neither Metformin nor ribavirin showed synergy with 5-FU in HT29 or HCT116 when combined in nontoxic concentrations when combined in nontoxic concentrations. Metformin and ribavirin significantly sensitized HT29 to oxaliplatin and only ribavirin synergized with oxaliplatin in HCT116 cell line. (b) HT29 and HCT116 differed significantly in their response to Compound 968 (P < 0.05). IC50 = 50% inhibitory concentration, 5-FU = 5-fluorouracil

Figure 1: Survival curves and histogram showing IC50. (a) Metformin and ribavirin Neither Metformin nor ribavirin showed synergy with 5-FU in HT29 or HCT116 when combined in nontoxic concentrations when combined in nontoxic concentrations. Metformin and ribavirin significantly sensitized HT29 to oxaliplatin and only ribavirin synergized with oxaliplatin in HCT116 cell line. (b) HT29 and HCT116 differed significantly in their response to Compound 968 (<i>P</i> < 0.05). IC<sub>50</sub> = 50% inhibitory concentration, 5-FU = 5-fluorouracil