Journal of Cancer Research and Therapeutics Close
 

Figure 1: Infi ltration of NK cells in tumor tissues and their relationship with cytokines and DCs. When small doses of IL-2 (5000 U) were injected, the number of NK cells infi ltrating the tumor tissues was approximately 50/mm2. By contrast, when high doses of IL-2 (50,000 U) were administered, the number of NK cells infi ltrating the tumor tissues was found to be as high as 65 ± 5 per mm2 (P < 0.005). When small doses of IL-15 (0.2 μg) were injected, the number of NK cells infi ltrating the tumor tissues was approximately 60/mm2. When IL-15 was administered at a dose of 1 μg, the number of NK cells infi ltrating the tumor tissues increased (P < 0.02). Moreover, when IL-15 was administered at a dose of 2 μg, the number of NK cells infi ltrating the tumor tissues signifi cantly increased (P < 0.005). When the ratio of DCs and NK cells was 1:10, the numbers of infi ltrating NK cells was approximately 75/mm2. In addition, when the ratio of DCs and NK cells was 1:1, the infi ltration number of NK cells increased (P < 0.02). When the ratio of DC and NK cells was 10:1, the numbers of infi ltrating NK cells did not signifi cantly increase (P > 0.05)

Figure 1: Infi ltration of NK cells in tumor tissues and their relationship with cytokines and DCs. When small doses of IL-2 (5000 U) were injected, the number of NK cells infi ltrating the tumor tissues was approximately 50/mm2. By contrast, when high doses of IL-2 (50,000 U) were administered, the number of NK cells infi ltrating the tumor tissues was found to be as high as 65 ± 5 per mm2 (P < 0.005). When small doses of IL-15 (0.2 μg) were injected, the number of NK cells infi ltrating the tumor tissues was approximately 60/mm2. When IL-15 was administered at a dose of 1 μg, the number of NK cells infi ltrating the tumor tissues increased (P < 0.02). Moreover, when IL-15 was administered at a dose of 2 μg, the number of NK cells infi ltrating the tumor tissues signifi cantly increased (P < 0.005). When the ratio of DCs and NK cells was 1:10, the numbers of infi ltrating NK cells was approximately 75/mm2. In addition, when the ratio of DCs and NK cells was 1:1, the infi ltration number of NK cells increased (P < 0.02). When the ratio of DC and NK cells was 10:1, the numbers of infi ltrating NK cells did not signifi cantly increase (P > 0.05)